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Introduction

Alzheimer’s disease is a neurodegenerative disorder that affects millions of people worldwide, with no cure currently available. One of the key players in the pathogenesis of Alzheimer’s disease is the tau protein. Tau is a microtubule-associated protein that is found predominantly in neurons and plays a crucial role in stabilizing microtubules. In Alzheimer’s disease, tau becomes hyperphosphorylated and aggregates into neurofibrillary tangles, leading to neuronal dysfunction and cell death. Understanding the role of tau protein in Alzheimer’s disease is essential for the development of effective treatments.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review

2.1 Overview of Alzheimer’s disease
2.2 Pathogenesis of Alzheimer’s disease
2.3 Role of tau protein in normal brain function
2.4 Tau pathology in Alzheimer’s disease
2.5 Tau imaging techniques
2.6 Current therapeutic strategies targeting tau
2.7 Animal models of tauopathy
2.8 Genetic factors influencing tau pathology
2.9 Tau protein in other neurodegenerative disorders
2.10 Future directions in tau research

Chapter 3: Research Methodology

3.1 Research design
3.2 Sampling method
3.3 Data collection techniques
3.4 Data analysis procedures
3.5 Ethical considerations
3.6 Reliability and validity of data
3.7 Research limitations
3.8 Research challenges

Chapter 4: Discussion of Findings

4.1 Overview of findings
4.2 Relationship between tau pathology and cognitive decline
4.3 Mechanisms of tau aggregation
4.4 Tau as a potential therapeutic target
4.5 The role of inflammation in tau pathology
4.6 Tau phosphorylation and neuronal dysfunction
4.7 Tau imaging in Alzheimer’s disease
4.8 Clinical implications of tau research

Chapter 5: Conclusion and Summary

In conclusion, the role of tau protein in Alzheimer’s disease is a complex and multifaceted topic that requires further investigation. By understanding the mechanisms underlying tau pathology, researchers can develop targeted therapies to slow or halt the progression of Alzheimer’s disease. This thesis provides a comprehensive overview of the current knowledge on tau protein in Alzheimer’s disease and highlights areas for future research.

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