the role of autophagy in cancer – Complete Phd and Masters Thesis

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Introduction

Autophagy is a highly conserved catabolic process that involves the degradation of cellular components through the lysosomal machinery. It plays a crucial role in maintaining cellular homeostasis by removing damaged organelles, misfolded proteins, and other cellular debris. Dysregulation of autophagy has been implicated in various human diseases, including cancer.

Cancer is a leading cause of death worldwide, characterized by uncontrolled cell growth and proliferation. Emerging evidence suggests that autophagy plays a dual role in cancer, acting as both a tumor suppressor and a tumor promoter. On one hand, autophagy serves as a protective mechanism against cancer by eliminating damaged cellular components and preventing the accumulation of potentially oncogenic mutations. On the other hand, cancer cells can hijack the autophagic process to promote their survival and growth under stressful conditions, such as nutrient deprivation and hypoxia.

Understanding the intricate relationship between autophagy and cancer is crucial for the development of novel therapeutic strategies targeting this pathway. This thesis aims to explore the role of autophagy in cancer and its implications for cancer therapy. The following chapters will provide a comprehensive review of the literature, research methodology, findings, and conclusions related to this topic.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Autophagy
2.2 Autophagy and Cancer
2.3 Autophagy as a Tumor Suppressor
2.4 Autophagy as a Tumor Promoter
2.5 Crosstalk between Autophagy and Apoptosis
2.6 Autophagy and Cancer Metabolism
2.7 Autophagy and Tumor Microenvironment
2.8 Targeting Autophagy in Cancer Therapy
2.9 Resistance to Autophagy Inhibitors
2.10 Future Perspectives

Chapter 3: Research Methodology
3.1 Study Design
3.2 Data Collection
3.3 Data Analysis
3.4 Cell Culture and Molecular Biology Techniques
3.5 Animal Models
3.6 Autophagy Assays
3.7 Drug Screening
3.8 Statistical Analysis

Chapter 4: Discussion of Findings
4.1 Role of Autophagy in Cancer Progression
4.2 Mechanisms of Autophagy Regulation in Cancer
4.3 Therapeutic Targeting of Autophagy in Cancer
4.4 Challenges and Future Directions

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Cancer Therapy
5.3 Future Research Directions

Thesis Overview

Autophagy is a fundamental cellular process that plays a critical role in maintaining cellular homeostasis and responding to various stresses. In the context of cancer, autophagy has emerged as a double-edged sword, exerting both tumor-suppressive and tumor-promoting functions. This thesis aims to provide a comprehensive overview of the role of autophagy in cancer, exploring its molecular mechanisms, regulatory pathways, and therapeutic implications.

The literature review will delve into the current understanding of autophagy in cancer, highlighting its complex interplay with tumor progression, metabolism, and the tumor microenvironment. The research methodology section will outline the experimental approaches used to investigate the role of autophagy in cancer, including cell culture techniques, animal models, autophagy assays, and drug screening methods.

The discussion of findings will present the key discoveries in the field, shedding light on the mechanisms by which autophagy influences cancer progression and therapy resistance. Finally, the conclusion and summary chapter will synthesize the main findings of the thesis, discussing their implications for cancer therapy and proposing future research directions in this exciting area of study.

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