[ad_1] Introduction In recent years, there has been a growing recognition of the need for a more comprehensive approach to drug development in pediatric populations. Physiologically based pharmacokinetic (PBPK) models have emerged as a valuable…
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[ad_1] Introduction Drug efficacy and mechanisms of action are critical aspects of pharmacology and are essential for understanding the effects of drugs on the human body. The efficacy of a drug refers to its ability…
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[ad_1] Introduction Biomarkers are measurable substances or indicators that can be used to assess biological processes, disease progression, or responses to treatment. In the field of safety, biomarkers play a crucial role in identifying potential…
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[ad_1] Introduction: The field of pharmacology has made tremendous advancements in recent years, owing to the development and application of computational tools in systems pharmacology and polypharmacology. These tools have enabled researchers to understand the…
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[ad_1] In recent years, drug delivery technologies for ocular disorders have become increasingly important as advances in medicine have allowed for more targeted and efficient treatments. The eye is a complex and unique organ with…
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[ad_1] Introduction Pharmacogenomics is a rapidly evolving field that aims to personalize medicine by studying how an individual’s genetic makeup influences their response to drugs. Drug-drug interactions and adverse events are common challenges in clinical…
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[ad_1] Introduction In recent years, microdosing has emerged as a promising strategy in early drug development. Microdosing involves the administration of sub-therapeutic doses of a drug to human subjects in order to study its pharmacokinetics…
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[ad_1] Introduction Distribution and elimination sites play a crucial role in the pharmacokinetics and pharmacodynamics of drugs. Understanding the processes involved in distribution and elimination is essential for optimizing drug therapy and minimizing adverse effects.…
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[ad_1] Introduction Drug-tissue interactions at absorption play a crucial role in determining the pharmacokinetics and pharmacodynamics of drugs in the body. Understanding how drugs interact with various tissues during the absorption process is essential for…
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[ad_1] Introduction Drug transporters at the blood-CSF barrier play a crucial role in regulating the passage of therapeutic agents from the systemic circulation into the central nervous system (CNS). Understanding the mechanisms by which these…
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