[ad_1] Introduction Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache, often accompanied by nausea, vomiting, and sensitivity to light and sound. It affects over 1 billion people worldwide and is…
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[ad_1] Introduction Genetic variability plays a crucial role in determining individual differences in drug metabolism. The inter-individual variability in response to drugs can be attributed to genetic factors that influence the metabolism of drugs in…
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[ad_1] Introduction Serotonin reuptake inhibitors, commonly known as SSRIs, are a class of medications that are primarily used to treat depression, anxiety disorders, and other mental health conditions. These medications work by increasing the levels…
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[ad_1] Introduction Drug-drug interactions (DDIs) have been recognized as a significant concern in healthcare, as they can lead to adverse effects, decreased therapeutic efficacy, and even treatment failure. Transporters, particularly membrane transport proteins such as…
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[ad_1] Introduction The blood-brain barrier (BBB) is a highly selective semipermeable membrane that separates the circulating blood from the brain extracellular fluid in order to protect the brain from potentially harmful substances. However, this barrier…
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[ad_1] Introduction Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system and plays a crucial role in the regulation of neuronal excitability. Drugs that target the GABAergic system have been…
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[ad_1] Introduction Hypertension, also known as high blood pressure, is a common chronic condition that affects millions of people worldwide. It is a major risk factor for cardiovascular diseases, stroke, and kidney failure. Pharmacological management…
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[ad_1] Introduction: Evaluation of drug-induced QT prolongation is a crucial aspect of pharmacovigilance as it is associated with an increased risk of life-threatening cardiac arrhythmias, such as Torsades de Pointes. QT prolongation occurs when the…
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[ad_1] Introduction Inflammation is a natural response by the body to injury or infection, but if left unchecked, it can lead to chronic inflammatory conditions such as arthritis, asthma, and inflammatory bowel disease. Anti-inflammatory drugs…
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[ad_1] Introduction Pharmacogenetics is a rapidly growing field that investigates the role of genetic variations in drug response. Antidepressant drugs are among the most commonly prescribed medications worldwide, yet there is significant variability in individual…
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