[ad_1] Introduction Drug-induced nephrotoxicity is a major concern in the field of medicine, as it can lead to serious renal dysfunction and even kidney failure in patients. Nephrotoxicity refers to the toxicity or damage caused…
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[ad_1] Introduction Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of heart disease, stroke, and type 2 diabetes. The prevalence of metabolic syndrome is on the rise globally, making it…
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[ad_1] Introduction Drug-drug interactions (DDIs) have been recognized as a significant concern in healthcare, as they can lead to adverse effects, decreased therapeutic efficacy, and even treatment failure. Transporters, particularly membrane transport proteins such as…
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[ad_1] Introduction The blood-brain barrier (BBB) is a highly selective semipermeable membrane that separates the circulating blood from the brain extracellular fluid in order to protect the brain from potentially harmful substances. However, this barrier…
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[ad_1] Introduction Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system and plays a crucial role in the regulation of neuronal excitability. Drugs that target the GABAergic system have been…
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[ad_1] Introduction: The Role of oxidative stress in drug-induced toxicity is a complex and multifaceted issue that has garnered increasing attention in the field of pharmacology and toxicology. Oxidative stress occurs when there is an…
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[ad_1] Introduction The field of drug discovery and development has continuously evolved over the years, with researchers constantly exploring new strategies to target various biological processes. One such area of interest is the development of…
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[ad_1] Introduction Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to organ dysfunction and failure. Despite advancements in critical care medicine, sepsis remains a major challenge in healthcare, with…
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[ad_1] Introduction Hypertension, also known as high blood pressure, is a common chronic condition that affects millions of people worldwide. It is a major risk factor for cardiovascular diseases, stroke, and kidney failure. Pharmacological management…
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[ad_1] Introduction: Evaluation of drug-induced QT prolongation is a crucial aspect of pharmacovigilance as it is associated with an increased risk of life-threatening cardiac arrhythmias, such as Torsades de Pointes. QT prolongation occurs when the…
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