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Introduction

Epilepsy is a neurological disorder characterized by recurrent seizures that affect millions of people worldwide. Despite advances in pharmacological treatments, there are still many individuals who do not respond to traditional medications. This has led researchers to explore alternative mechanisms underlying epilepsy, including neurovascular interactions.

Neurovascular interactions refer to the communication between neurons and blood vessels in the brain. Research has shown that changes in blood flow and vascular function can influence neuronal activity and potentially contribute to the development of seizures. Understanding the complex relationship between neurons and blood vessels may provide new insights into the pathophysiology of epilepsy and lead to novel treatment strategies.

This thesis aims to investigate the role of neurovascular interactions in epilepsy. By examining how changes in blood flow and vascular function affect neuronal activity, we hope to uncover new mechanisms underlying seizure generation and identify potential targets for therapeutic intervention. This research has the potential to enhance our understanding of epilepsy and improve treatment outcomes for individuals with this debilitating condition.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of epilepsy
2.2 Neurovascular interactions in epilepsy
2.3 Role of blood flow in seizure generation
2.4 Vascular dysfunction in epilepsy
2.5 Current treatment approaches
2.6 Potential therapeutic targets
2.7 Animal models of epilepsy
2.8 Imaging techniques in neurovascular research
2.9 Neuroinflammation and epilepsy
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Study design
3.2 Participants
3.3 Data collection
3.4 Data analysis
3.5 Ethical considerations
3.6 Experimental procedures
3.7 Neuroimaging techniques
3.8 Statistical analysis

Chapter 4: Discussion of Findings
4.1 Neurovascular interactions in epilepsy
4.2 Impact of blood flow on seizure activity
4.3 Vascular changes in epilepsy
4.4 Potential therapeutic targets
4.5 Clinical implications
4.6 Future research directions

Chapter 5: Conclusion
5.1 Summary of findings
5.2 Implications for epilepsy research
5.3 Limitations of the study
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview

The study of neurovascular interactions in epilepsy is a rapidly evolving field that holds great promise for the development of new treatment strategies. This thesis aims to investigate how changes in blood flow and vascular function contribute to seizure generation in individuals with epilepsy. By examining the complex relationship between neurons and blood vessels, we hope to uncover novel mechanisms underlying epilepsy and identify potential targets for therapeutic intervention.

The literature review will provide a comprehensive overview of current research on neurovascular interactions in epilepsy, including the role of blood flow, vascular dysfunction, and potential therapeutic targets. The research methodology section will outline the study design, participant recruitment, data collection methods, and statistical analysis procedures.

The discussion of findings will present the results of our research and examine the implications for epilepsy research and clinical practice. We will also discuss the limitations of our study and make recommendations for future research in this area. In conclusion, this thesis will summarize our findings, highlight the importance of studying neurovascular interactions in epilepsy, and suggest avenues for further exploration.

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