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Introduction:

Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of individuals worldwide, particularly the elderly population. Extensive research has been conducted to understand the underlying mechanisms of the disease, but many aspects still remain unknown. One emerging area of study is the role of neuroimmune interactions in Alzheimer’s disease.

The interaction between the nervous system and the immune system is crucial for maintaining homeostasis and responding to insults such as pathogens or tissue damage. Dysfunction in neuroimmune interactions has been implicated in various neurological disorders, and recent evidence suggests that it may play a significant role in the pathogenesis of Alzheimer’s disease.

This thesis aims to investigate the role of neuroimmune interactions in Alzheimer’s disease, with a focus on the inflammatory response and its impact on disease progression. By understanding the complex interplay between the nervous and immune systems in the context of Alzheimer’s disease, this research may provide insights into potential therapeutic targets for intervention.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Neuroinflammation in Alzheimer’s disease
2.2 Immune cells in the brain
2.3 Role of microglia in neuroinflammation
2.4 Cytokines and chemokines in Alzheimer’s disease
2.5 Blood-brain barrier dysfunction in Alzheimer’s disease
2.6 Neuroimmune communication pathways
2.7 Neuroimmune interactions in aging
2.8 Genetic factors in neuroinflammation
2.9 Therapeutic interventions targeting neuroinflammation
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Statistical analysis
3.8 Limitations of the study

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Implications for Alzheimer’s disease pathogenesis
4.3 Comparison with existing literature
4.4 Future research directions
4.5 Clinical relevance
4.6 Practical implications
4.7 Strengths and limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field
5.3 Practical implications
5.4 Recommendations for future research
5.5 Conclusion

This thesis will provide a comprehensive examination of neuroimmune interactions in Alzheimer’s disease, aiming to advance our understanding of the disease pathology and potential therapeutic strategies.

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