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Introduction

Proteins play crucial roles in various biological processes and are often targeted by inhibitors in drug development efforts. Understanding the structural details of protein-inhibitor complexes is important for designing more effective and specific inhibitors. This thesis focuses on structural studies of protein-inhibitor complexes, aiming to elucidate the molecular mechanisms of inhibition and provide insights for rational drug design.

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of proteins and inhibitors
2.2 Methods for studying protein-inhibitor complexes
2.3 Structural biology techniques
2.4 Protein-ligand docking studies
2.5 Recent advances in structural studies of protein-inhibitor complexes
2.6 Protein dynamics and binding kinetics
2.7 Drug resistance mechanisms
2.8 Structural basis for inhibitor selectivity
2.9 Computational approaches for drug design
2.10 Future directions in the field

Chapter 3: Research Methodology
3.1 Selection of protein targets
3.2 Inhibitor screening and selection
3.3 Protein expression and purification
3.4 X-ray crystallography studies
3.5 NMR spectroscopy studies
3.6 Molecular modeling and docking
3.7 Binding affinity measurements
3.8 Data analysis and interpretation

Chapter 4: Discussion of Findings
4.1 Structural analysis of protein-inhibitor complexes
4.2 Mechanisms of inhibition
4.3 Binding interactions and key residues
4.4 Structural basis for inhibitor potency
4.5 Comparison with other inhibitors
4.6 Implications for drug design
4.7 Limitations of the study
4.8 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for drug discovery
5.3 Contributions to the field
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview:

The structural studies of protein-inhibitor complexes play a critical role in modern drug discovery efforts. This thesis focuses on investigating the molecular interactions between proteins and inhibitors to understand the mechanisms of inhibition and provide insights for rational drug design. The literature review covers the background of proteins and inhibitors, methods for studying protein-ligand interactions, and recent advances in the field. The research methodology details the experimental approaches used to study protein-inhibitor complexes, including protein expression and purification, X-ray crystallography, NMR spectroscopy, and molecular modeling. The discussion of findings analyzes the structural details of protein-inhibitor complexes, elucidates the mechanisms of inhibition, and discusses the implications for drug design. The conclusion summarizes the key findings, discusses the contributions to the field, and provides recommendations for future research.

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