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Introduction

Drug resistance is a growing concern in the field of medicine, posing a significant challenge to the effectiveness of pharmacological treatments. Resistance mechanisms can be attributed to a variety of factors, including genetic mutations, drug metabolism, and the overexpression of efflux transporters. Transporters play a crucial role in drug resistance by actively pumping drugs out of cells, thereby reducing their intracellular concentrations and efficacy. Understanding the role of transporters in drug resistance is essential for developing strategies to overcome this phenomenon and improve patient outcomes.

Chapter 1: Role of transporters in drug resistance

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature review

2.1 Overview of drug resistance mechanisms
2.2 Role of transporters in drug efflux
2.3 Transporter families implicated in drug resistance
2.4 Mechanisms of transporter-mediated drug resistance
2.5 Clinical relevance of transporter-mediated drug resistance
2.6 Strategies to overcome transporter-mediated drug resistance
2.7 Experimental models for studying transporter-mediated drug resistance
2.8 Emerging research in transporter-mediated drug resistance
2.9 Gaps in current knowledge
2.10 Summary of key findings

Chapter 3: Research methodology

3.1 Research design
3.2 Sample selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Statistical analysis
3.7 Validation of results
3.8 Research limitations

Chapter 4: Discussion of findings

4.1 Overview of study findings
4.2 Relationship between transporters and drug resistance
4.3 Implications for clinical practice
4.4 Comparison with existing literature
4.5 Limitations of the study
4.6 Future research directions

Chapter 5: Conclusion and summary

5.1 Summary of key findings
5.2 Implications for the field
5.3 Recommendations for further research
5.4 Conclusion

Thesis Overview on Role of transporters in drug resistance

The phenomenon of drug resistance has become a major obstacle in the treatment of various diseases, including cancer and infectious diseases. Efflux transporters play a crucial role in drug resistance by actively pumping drugs out of cells, thereby reducing their intracellular concentrations and efficacy. This thesis will provide an in-depth analysis of the role of transporters in drug resistance, focusing on the mechanisms involved, the transporter families implicated, and strategies to overcome transporter-mediated drug resistance. By understanding the complex interplay between transporters and drug resistance, this research aims to contribute to the development of novel therapeutic approaches that can improve patient outcomes and combat the growing problem of drug resistance.

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