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Introduction

Polyglutamine (polyQ) repeats are stretches of consecutive glutamine residues found in numerous proteins, with the length of the repeat varying among different proteins. These repeats have been implicated in the pathogenesis of several neurodegenerative diseases, including Huntington’s disease, spinocerebellar ataxias, and spinal bulbar muscular atrophy. Despite the growing body of research on polyQ repeats, their exact role in protein function and disease pathogenesis remains unclear.

This thesis aims to investigate the role of polyQ repeats in protein function, with a focus on understanding the molecular mechanisms underlying their involvement in neurodegenerative diseases. By elucidating the biological processes affected by polyQ repeats, this research has the potential to contribute to the development of novel therapeutic strategies for treating these devastating disorders.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Historical perspective on polyQ repeats
2.2 Genetics of polyQ diseases
2.3 Structural and functional implications of polyQ repeats
2.4 Protein aggregation and toxicity
2.5 Cellular pathways affected by polyQ repeats
2.6 Animal models of polyQ diseases
2.7 Therapeutic strategies for polyQ diseases
2.8 Current challenges in polyQ research
2.9 Future directions in polyQ research
2.10 Conclusion

Chapter 3: Research Methodology
3.1 Selection of protein models
3.2 Generation of polyQ repeat constructs
3.3 Cell culture techniques
3.4 Protein expression and purification
3.5 Biophysical characterization
3.6 Cell-based assays
3.7 Bioinformatic analysis
3.8 Statistical methods

Chapter 4: Discussion of Findings
4.1 Characterization of polyQ repeat proteins
4.2 Effects of polyQ repeats on protein structure
4.3 Cellular consequences of polyQ repeat expansion
4.4 Comparative analysis of different polyQ diseases
4.5 Implications for therapeutic development
4.6 Novel insights into polyQ biology
4.7 Limitations of the study
4.8 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for the field
5.3 Contribution to knowledge
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview: Role of Polyglutamine Repeats in Protein Function

Polyglutamine (polyQ) repeats are short stretches of glutamine residues found in many proteins, and their expansion has been linked to several neurodegenerative diseases. This thesis aims to investigate the role of polyQ repeats in protein function, with a focus on understanding their impact on disease pathogenesis. The literature review will provide a comprehensive overview of current knowledge on polyQ repeats, while the research methodology will detail the experimental approaches used in this study. The discussion of findings will present the results of our investigations, including the effects of polyQ repeats on protein structure and function. Finally, the conclusion and summary will highlight the significance of our findings and propose future research directions in the field of polyQ biology.

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