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Introduction

Psoriasis is a chronic autoimmune skin disorder that affects millions of people worldwide. It is characterized by red, scaly patches on the skin, which can cause itching, pain, and discomfort. While the exact cause of psoriasis is unknown, it is believed to be a combination of genetic, environmental, and immunological factors. There is currently no cure for psoriasis, but there are various pharmacological interventions available to help manage the symptoms and improve the quality of life for patients.

This thesis will explore the various pharmacological interventions in psoriasis, including traditional systemic treatments, biologic therapies, and emerging therapies. The goal is to provide a comprehensive overview of the current treatment options available for psoriasis and to highlight the potential benefits and limitations of each approach.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of the study
1.3 Problem statement
1.4 Objective of the study
1.5 Limitation of the study
1.6 Scope of the study
1.7 Significance of the study
1.8 Structure of the thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 History of psoriasis treatment
2.2 Traditional systemic treatments
2.3 Biologic therapies
2.4 Emerging therapies
2.5 Efficacy and safety of pharmacological interventions
2.6 Adherence and compliance issues
2.7 Cost-effectiveness of treatment options
2.8 Patient preferences and quality of life outcomes
2.9 Combination therapies
2.10 Future directions in psoriasis treatment

Chapter 3: Research Methodology
3.1 Research design
3.2 Sampling methods
3.3 Data collection
3.4 Data analysis
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Research limitations
3.8 Research implications

Chapter 4: Discussion of Findings
4.1 Comparison of treatment options
4.2 Adherence and compliance issues
4.3 Cost-effectiveness of therapies
4.4 Patient preferences and quality of life outcomes
4.5 Combination therapies
4.6 Safety and efficacy considerations
4.7 Unmet needs in psoriasis treatment
4.8 Recommendations for clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview on Pharmacological Interventions in Psoriasis

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the global population. It is characterized by red, scaly patches on the skin, which can be itchy, painful, and cosmetically distressing. While the exact cause of psoriasis is unknown, it is believed to be a complex interplay of genetic, environmental, and immunological factors.

Pharmacological interventions are a cornerstone of psoriasis treatment, aimed at reducing inflammation, slowing down skin cell turnover, and alleviating symptoms. Traditional systemic treatments such as methotrexate and cyclosporine have been used for decades and are effective for many patients. However, these medications can have serious side effects and long-term risks.

Biologic therapies have revolutionized the treatment of psoriasis in the past two decades, offering targeted therapy with fewer systemic side effects. These medications work by targeting specific molecules involved in the inflammatory process, such as tumor necrosis factor-alpha and interleukins. Biologics have shown high efficacy in clinical trials and are generally well-tolerated by patients.

Despite the advancements in pharmacological interventions, there are still challenges in the management of psoriasis. Adherence and compliance issues are common, as some treatments require frequent injections or infusions. Cost-effectiveness is also a concern, as biologic therapies can be expensive and may not be accessible to all patients. Additionally, the long-term safety of these medications is still being studied.

This thesis will review the current literature on pharmacological interventions in psoriasis, including traditional systemic treatments, biologic therapies, and emerging therapies. The research methodology will involve a systematic review of randomized controlled trials, cohort studies, and observational studies to evaluate the efficacy, safety, and cost-effectiveness of different treatment options. The findings will be discussed in relation to adherence and compliance issues, patient preferences, and quality of life outcomes.

Overall, this thesis aims to provide a comprehensive overview of the pharmacological interventions in psoriasis, highlighting the benefits and limitations of each approach. It will also make recommendations for clinical practice and future research directions to improve the management of this complex skin disorder.

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