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Introduction

Dupuytrenʼs contracture is a progressive fibroproliferative disorder that affects the palmar fascia of the hand, resulting in the formation of nodules and cords that can lead to deformity and loss of hand function. While surgical interventions have traditionally been the mainstay of treatment for Dupuytrenʼs contracture, pharmacological interventions are emerging as a promising alternative or adjunctive therapy. These interventions aim to target the underlying pathophysiology of the disease, including abnormal collagen deposition and myofibroblast proliferation, to prevent or slow down disease progression.

This thesis aims to provide a comprehensive overview of pharmacological interventions in Dupuytrenʼs contracture, including a review of the current literature, analysis of research methodologies, and discussion of findings. The objective is to evaluate the efficacy and safety of pharmacological interventions, identify potential limitations and propose future directions for research in this field.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Dupuytrenʼs contracture
2.2 Pathophysiology of Dupuytrenʼs contracture
2.3 Current treatment options
2.4 Emerging pharmacological interventions
2.5 Collagenase injections
2.6 Antifibrotic agents
2.7 Anti-inflammatory drugs
2.8 Growth factor inhibitors
2.9 Matrix metalloproteinase inhibitors
2.10 Combination therapies

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant selection
3.3 Intervention protocols
3.4 Outcome measures
3.5 Data analysis
3.6 Ethical considerations
3.7 Funding sources
3.8 Timeline

Chapter 4: Discussion of Findings
4.1 Efficacy of pharmacological interventions
4.2 Safety profiles
4.3 Adverse effects
4.4 Patient satisfaction
4.5 Cost-effectiveness
4.6 Comparison with surgical interventions
4.7 Future research directions
4.8 Implications for clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

Pharmacological interventions in Dupuytrenʼs contracture represent a promising avenue for the treatment of this debilitating hand condition. This thesis will provide a comprehensive review of the current literature on pharmacological interventions, with a focus on collagenase injections, antifibrotic agents, anti-inflammatory drugs, growth factor inhibitors, and matrix metalloproteinase inhibitors. The research methodology will be discussed in detail, including study design, participant selection, intervention protocols, outcome measures, data analysis, ethical considerations, funding sources, and timeline. The findings of the study will be critically analyzed, with a focus on efficacy, safety, adverse effects, patient satisfaction, cost-effectiveness, and comparison with surgical interventions. The implications for clinical practice and recommendations for future research will be outlined in the conclusion.

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