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**Introduction**

Optogenetics is a powerful technique that allows for precise control over the activity of specific neuron populations using light. This technology has revolutionized the field of neuroscience by providing researchers with a tool to investigate the neural circuits underlying various cognitive functions. One such cognitive function that has been extensively studied using optogenetics is sensory gating, which is the process by which the brain filters out irrelevant sensory information in order to focus on relevant stimuli.

This thesis focuses on the application of optogenetic modulation of sensory gating and its implications for understanding the neural basis of this important cognitive process. By selectively controlling the activity of specific neurons involved in sensory gating, researchers can gain insights into how these neurons contribute to sensory processing and perception.

**Table of Contents**

1.1 Introduction

1.2 Background of study

1.3 Problem Statement

1.4 Objective of study

1.5 Limitation of study

1.6 Scope of study

1.7 Significance of study

1.8 Structure of the Thesis

1.9 Definition of terms

2. Literature review
– Overview of optogenetics
– Sensory gating in cognitive neuroscience
– Previous studies on optogenetic modulation of sensory gating
– Neural circuits involved in sensory gating
– Role of specific neuronal populations in sensory gating
– Effects of sensory gating deficits on cognition
– Techniques for measuring sensory gating
– Current challenges in studying sensory gating using optogenetics
– Future directions in optogenetic modulation of sensory gating research
– Conclusion of literature review

3. Research methodology
– Selection of animal models
– Optogenetic tools and techniques
– Experimental design and procedures
– Data collection and analysis methods
– Ethical considerations
– Potential limitations and biases
– Statistical analysis
– Validation of results
– Conclusion of research methodology

4. Discussion of findings
– Effects of optogenetic modulation on sensory gating
– Neural mechanisms underlying sensory gating
– Interactions between different neuronal populations in sensory gating
– Implications for understanding sensory processing disorders
– Comparison with traditional methods of studying sensory gating
– Future directions in research on optogenetic modulation of sensory gating
– Conclusion of discussion of findings

5. Conclusion and summary
– Recap of key findings
– Implications for neuroscience and cognitive psychology
– Limitations and challenges
– Recommendations for future research
– Conclusion of thesis on optogenetic modulation of sensory gating

**Thesis Overview**

Optogenetic modulation of sensory gating is an emerging field in neuroscience that holds great promise for advancing our understanding of how the brain filters out irrelevant sensory information. This thesis aims to provide a comprehensive review of the current literature on the topic, as well as present original research findings on the effects of optogenetic manipulation on sensory gating in animal models.

In the literature review chapter, an overview of optogenetics and sensory gating will be provided, along with a discussion of previous studies and future directions in the field. The research methodology chapter will detail the experimental design, data collection methods, and analysis techniques used in the study.

The discussion of findings chapter will present the results of the experiments, including the effects of optogenetic modulation on sensory gating, the neural mechanisms underlying this process, and the implications for understanding sensory processing disorders. The conclusion and summary chapter will summarize the key findings, discuss the limitations and challenges of the research, and provide recommendations for future studies in this area.

Overall, this thesis aims to contribute to the growing body of knowledge on optogenetic modulation of sensory gating and its implications for cognitive neuroscience. By shedding light on the neural circuits involved in sensory gating, this research has the potential to inform new therapeutic approaches for individuals with sensory processing disorders.

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