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Introduction:

Schizophrenia is a severe and chronic mental disorder that affects approximately 1% of the global population. Despite considerable advancements in our understanding of the neurobiology of schizophrenia and the development of antipsychotic medications, many patients continue to experience debilitating symptoms and cognitive impairments. This has led to a growing interest in exploring novel therapeutic targets for the treatment of schizophrenia.

This thesis aims to investigate novel targets in the pathophysiology of schizophrenia and their potential implications for the development of new treatment strategies. By examining the latest research in this field, this study seeks to expand our knowledge of the underlying mechanisms of schizophrenia and contribute to the development of more effective therapies for this complex disorder.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Historical overview of schizophrenia research
2.2 Neurotransmitter systems in schizophrenia
2.3 Genetic factors in schizophrenia
2.4 Neuroinflammation and oxidative stress in schizophrenia
2.5 Neuroimaging studies in schizophrenia
2.6 Animal models of schizophrenia
2.7 Novel targets in schizophrenia: glutamatergic system
2.8 Novel targets in schizophrenia: immune system
2.9 Novel targets in schizophrenia: epigenetic mechanisms
2.10 Novel targets in schizophrenia: mitochondrial dysfunction

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Measures
3.4 Data collection procedures
3.5 Data analysis methods
3.6 Ethical considerations
3.7 Potential limitations
3.8 Future directions

Chapter 4: Discussion of Findings
4.1 Overview of study results
4.2 Implications for understanding the pathophysiology of schizophrenia
4.3 Potential clinical implications
4.4 Comparison with previous research
4.5 Strengths and limitations of the study
4.6 Future research directions
4.7 Theoretical and practical implications
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Practical implications for the treatment of schizophrenia
5.4 Limitations of the study
5.5 Recommendations for future research
5.6 Conclusion

Thesis Overview:

Schizophrenia is a complex and debilitating mental disorder that affects a significant portion of the global population. Despite advancements in our understanding of its neurobiology and the development of antipsychotic medications, many patients still struggle with persistent symptoms and cognitive impairments. This has prompted researchers to explore novel therapeutic targets for the treatment of schizophrenia.

This thesis aims to investigate novel targets in the pathophysiology of schizophrenia and their potential implications for the development of more effective treatment strategies. By conducting a comprehensive literature review and research methodology, this study seeks to expand our knowledge of the underlying mechanisms of schizophrenia and contribute to the development of personalized and targeted therapies for this challenging disorder. Through the discussion of findings and conclusion, this thesis will provide insights into the potential clinical implications and future research directions in the field of novel targets in schizophrenia.

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