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Introduction:

Pulmonary hypertension (PH) is a devastating disease characterized by elevated blood pressure within the pulmonary vasculature, leading to right heart failure and ultimately death. Despite advances in treatment options, the prognosis for patients with pulmonary hypertension remains poor, highlighting the need for novel therapeutic targets. This thesis aims to explore novel targets in pulmonary hypertension and their potential impact on disease management.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of pulmonary hypertension
2.2 Current treatment options
2.3 Pathophysiology of pulmonary hypertension
2.4 Endothelial dysfunction in pulmonary hypertension
2.5 Inflammatory pathways in pulmonary hypertension
2.6 Genetic factors in pulmonary hypertension
2.7 Metabolic dysregulation in pulmonary hypertension
2.8 Targeting the prostacyclin pathway
2.9 Novel therapeutic targets in pulmonary hypertension
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Study limitations
3.7 Research instruments
3.8 Data validation techniques

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Analysis of novel targets in pulmonary hypertension
4.3 Implications for disease management
4.4 Comparison to current treatment options
4.5 Future research directions
4.6 Limitations of the study
4.7 Recommendations for clinical practice
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Contribution to the field
5.4 Limitations of the study
5.5 Future research directions
5.6 Conclusion

Thesis Overview:

Pulmonary hypertension (PH) is a complex and debilitating disease that continues to pose significant challenges in terms of management and treatment. This thesis focuses on exploring novel targets in pulmonary hypertension, with the aim of identifying potential therapeutic strategies that could improve patient outcomes.

Chapter 1 provides an introduction to the study, including background information on pulmonary hypertension, the problem statement, objectives, limitations, scope, significance, and structure of the thesis. The chapter also defines key terms to ensure clarity throughout the document.

Chapter 2 presents a comprehensive literature review on pulmonary hypertension, covering current treatment options, pathophysiology, endothelial dysfunction, inflammatory pathways, genetic factors, metabolic dysregulation, and novel therapeutic targets. This chapter sets the stage for the subsequent research by establishing a solid foundation of existing knowledge in the field.

Chapter 3 outlines the research methodology, including study design, participant selection, data collection methods, data analysis techniques, ethical considerations, limitations, research instruments, and data validation techniques. This chapter provides insight into the approach taken to investigate novel targets in pulmonary hypertension.

Chapter 4 delves into a detailed discussion of the findings, analyzing the impact of novel targets on disease management, comparing them to current treatment options, identifying future research directions, discussing limitations, offering recommendations for clinical practice, and concluding the study.

Chapter 5 summarizes the key findings, discusses their implications for clinical practice, highlights the contribution to the field, addresses study limitations, suggests future research directions, and offers a conclusion on the thesis on Novel targets in pulmonary hypertension.

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