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Introduction

Recent advancements in cancer treatment have led to the development of targeted therapies that specifically block key signaling pathways involved in tumor growth and metastasis. One such pathway is the PI3K/Akt/mTOR pathway, which plays a crucial role in cell proliferation, survival, and metabolism. However, the emergence of resistance to PI3K inhibitors poses a significant challenge in the successful treatment of cancer patients.

This thesis aims to explore novel approaches to overcome PI3K inhibitor resistance and improve the efficacy of targeted therapies in cancer treatment. By investigating the mechanisms underlying drug resistance and identifying potential therapeutic targets, this research seeks to provide new insights into overcoming resistance and improving patient outcomes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Introduction to PI3K signaling pathway
2.2 Mechanisms of resistance to PI3K inhibitors
2.3 Current treatment strategies for PI3K inhibitor resistance
2.4 Novel therapeutic targets for overcoming resistance
2.5 Combination therapies to enhance PI3K inhibitor efficacy
2.6 Preclinical and clinical studies on overcoming resistance
2.7 Biomarkers for predicting response to PI3K inhibitors
2.8 Emerging trends in targeted cancer therapy
2.9 Challenges and future directions in PI3K inhibitor resistance research
2.10 Summary of key findings

Chapter 3: Research Methodology
3.1 Research design and approach
3.2 Study population and sample size
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Research limitations
3.7 Validation of results
3.8 Conclusion

Chapter 4: Discussion of Findings
4.1 Overview of research findings
4.2 Mechanisms of PI3K inhibitor resistance
4.3 Therapeutic targets for overcoming resistance
4.4 Combination therapies to enhance efficacy
4.5 Clinical implications of study results
4.6 Comparison with existing literature
4.7 Future directions for research
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview

The development of targeted therapies such as PI3K inhibitors has revolutionized cancer treatment by specifically targeting key signaling pathways involved in tumor growth. However, the emergence of resistance to these inhibitors poses a significant challenge in the successful treatment of cancer patients. This thesis aims to explore novel approaches to overcome PI3K inhibitor resistance and improve the efficacy of targeted therapies in cancer treatment.

The literature review will provide a comprehensive overview of the PI3K signaling pathway, mechanisms of resistance to PI3K inhibitors, current treatment strategies, novel therapeutic targets, combination therapies, biomarkers for predicting response, and emerging trends in targeted cancer therapy. The research methodology will detail the study design, population, sample size, data collection methods, analysis techniques, ethical considerations, limitations, and validation of results.

The discussion of findings will present an overview of research findings, mechanisms of resistance, therapeutic targets, combination therapies, clinical implications, comparison with existing literature, future research directions, and conclusion. The conclusion and summary chapter will summarize key findings, implications for clinical practice, recommendations for future research, and overall conclusion of the study. This thesis will provide valuable insights into overcoming PI3K inhibitor resistance and improving patient outcomes in cancer treatment.

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