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Introduction

Cancer remains one of the leading causes of death worldwide, with millions of new cases diagnosed each year. The mammalian target of rapamycin (mTOR) pathway plays a crucial role in cell growth, proliferation, and survival, making it an attractive target for cancer therapy. However, resistance to mTOR inhibitors poses a significant challenge in the treatment of cancer. Overcoming this resistance requires novel approaches that can enhance the efficacy of mTOR inhibitors and improve patient outcomes.

Chapter 1: Introduction
1.1 The Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of mTOR signaling pathway
2.2 Mechanisms of resistance to mTOR inhibitors
2.3 Current strategies to overcome mTOR inhibitor resistance
2.4 Combination therapies targeting mTOR pathway
2.5 Immunotherapy in combination with mTOR inhibitors
2.6 Epigenetic modifications and mTOR inhibitor resistance
2.7 Small molecule inhibitors of mTOR pathway
2.8 Nutrient sensing and mTOR pathway
2.9 Clinical trials investigating novel approaches to overcome mTOR inhibitor resistance
2.10 Future directions in targeting mTOR pathway in cancer therapy

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Sample size determination
3.7 Statistical analysis plan
3.8 Validation of results

Chapter 4: Discussion of Findings
4.1 Analysis of data
4.2 Comparison with existing literature
4.3 Implications of findings
4.4 Limitations of the study
4.5 Future research directions
4.6 Clinical relevance of findings
4.7 Practical implications
4.8 Recommendations for clinical practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to existing knowledge
5.3 Implications for future research
5.4 Practical applications
5.5 Conclusion

Thesis Overview on Novel Approaches to Overcome mTOR Inhibitor Resistance

The mammalian target of rapamycin (mTOR) pathway is a critical regulator of cell growth and survival, making it an attractive target for cancer therapy. However, resistance to mTOR inhibitors poses a significant challenge in the treatment of cancer. This thesis explores novel approaches to overcome mTOR inhibitor resistance and enhance the efficacy of mTOR-targeted therapies.

Chapter 1 provides an introduction to the research topic, including background information, problem statement, objectives of the study, limitations, scope, significance, and structure of the thesis. Chapter 2 presents a comprehensive review of the literature, covering the mTOR signaling pathway, mechanisms of resistance to mTOR inhibitors, current strategies to overcome resistance, combination therapies, immunotherapy, epigenetic modifications, small molecule inhibitors, nutrient sensing, and ongoing clinical trials.

Chapter 3 outlines the research methodology, including the study design, population, data collection methods, analysis techniques, ethical considerations, sample size determination, statistical analysis plan, and validation of results. Chapter 4 discusses the findings in detail, analyzing the data, comparing with existing literature, highlighting implications, addressing limitations, providing future research directions, and making recommendations for clinical practice.

Chapter 5 offers a conclusion and summary of the thesis, summarizing key findings, discussing contributions to existing knowledge, suggesting implications for future research, exploring practical applications, and providing a conclusion. This thesis aims to shed light on novel approaches to overcome mTOR inhibitor resistance and improve cancer therapy outcomes.

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