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Introduction

Histone deacetylase (HDAC) inhibitors are a class of compounds that have shown great promise in the treatment of various cancers by targeting epigenetic mechanisms. However, the development of resistance to HDAC inhibitors poses a significant challenge in their clinical efficacy. Novel approaches are needed to overcome this resistance and improve the outcomes for cancer patients. This thesis aims to explore innovative strategies to address HDAC inhibitor resistance and enhance their therapeutic potential.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review

2.1 Mechanisms of action of HDAC inhibitors
2.2 Resistance mechanisms to HDAC inhibitors
2.3 Current strategies to overcome HDAC inhibitor resistance
2.4 Novel approaches in HDAC inhibitor development
2.5 Role of epigenetic modifications in cancer progression
2.6 Preclinical and clinical studies on HDAC inhibitors
2.7 Biomarkers for predicting response to HDAC inhibitors
2.8 Combination therapy with HDAC inhibitors
2.9 Targeting specific HDAC isoforms
2.10 Future directions in HDAC inhibitor research

Chapter 3: Research Methodology

3.1 Research design
3.2 Study population
3.3 Data collection methods
3.4 Data analysis techniques
3.5 In vitro and in vivo experiments
3.6 Cell lines and animal models
3.7 Drug screening assays
3.8 Molecular profiling techniques

Chapter 4: Discussion of Findings

4.1 Mechanisms of HDAC inhibitor resistance
4.2 Experimental results on novel approaches
4.3 Comparison with existing strategies
4.4 Implications for clinical practice
4.5 Potential challenges and limitations
4.6 Future research directions

Chapter 5: Conclusion and Summary

In conclusion, this thesis provides a comprehensive review of the current literature on HDAC inhibitors and resistance mechanisms. Novel approaches, such as targeting specific isoforms and combination therapy, show promise in overcoming resistance and improving therapeutic outcomes. Further research is needed to validate these findings and translate them into clinical practice. By exploring innovative strategies to address HDAC inhibitor resistance, this thesis contributes to the advancement of personalized cancer therapy.

Thesis Overview

Histone deacetylase (HDAC) inhibitors have emerged as promising anticancer agents by targeting epigenetic mechanisms. However, the development of resistance to HDAC inhibitors poses a significant challenge in their clinical efficacy. This thesis focuses on exploring novel approaches to overcome HDAC inhibitor resistance and enhance their therapeutic potential.

Chapter 1 provides an introduction to the research topic, including the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. Chapter 2 presents a comprehensive literature review on the mechanisms of action of HDAC inhibitors, resistance mechanisms, current strategies to overcome resistance, novel approaches in HDAC inhibitor development, and future directions in research.

Chapter 3 details the research methodology, including study design, population, data collection, analysis methods, in vitro and in vivo experiments, cell lines, animal models, drug screening assays, and molecular profiling techniques. Chapter 4 discusses the findings of the study, including mechanisms of HDAC inhibitor resistance, experimental results on novel approaches, implications for clinical practice, potential challenges, and future research directions.

In the concluding chapter, Chapter 5 summarizes the key findings and implications of the research, emphasizing the importance of exploring innovative strategies to address HDAC inhibitor resistance. This thesis aims to contribute to the advancement of personalized cancer therapy and improve outcomes for cancer patients.

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