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Thesis Overview:

Title: Novel Approaches to Overcome CDK4/6 Inhibitor Resistance

Introduction:

CDK4/6 inhibitors have shown great promise in the treatment of various cancers, particularly in breast cancer. However, the development of resistance to these inhibitors remains a significant challenge in clinical practice. This thesis aims to explore novel approaches to overcoming CDK4/6 inhibitor resistance, with the ultimate goal of improving treatment outcomes for cancer patients.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of the Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Mechanisms of CDK4/6 Inhibitor Resistance
2.2 Current Approaches to Overcoming CDK4/6 Inhibitor Resistance
2.3 Role of Cell Cycle Regulators in CDK4/6 Inhibitor Resistance
2.4 Emerging Therapeutic Targets for Overcoming CDK4/6 Inhibitor Resistance
2.5 Clinical Studies on Novel Approaches to CDK4/6 Inhibitor Resistance
2.6 Biomarkers of CDK4/6 Inhibitor Resistance
2.7 Combination Therapies for Overcoming CDK4/6 Inhibitor Resistance
2.8 Resistance Reversal Strategies
2.9 Future Perspectives in Overcoming CDK4/6 Inhibitor Resistance
2.10 Summary of Literature Review

Chapter 3: Research Methodology
3.1 Research Design
3.2 Data Collection Methods
3.3 Sample Selection
3.4 Data Analysis Techniques
3.5 Ethical Considerations
3.6 Pilot Testing
3.7 Validation Methods
3.8 Limitations of Research Methodology

Chapter 4: Discussion of Findings
4.1 Analysis of Research Findings
4.2 Comparison with Existing Literature
4.3 Implications of Findings
4.4 Recommendations for Future Research
4.5 Practical Applications of Findings

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Contribution to Knowledge
5.3 Practical Implications
5.4 Limitations of Study
5.5 Recommendations for Future Research

This thesis will provide valuable insights into novel approaches to overcoming CDK4/6 inhibitor resistance, with the potential to improve patient outcomes and advance the field of cancer therapeutics.

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