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Thesis Overview:

Title: Novel Approaches to Overcome BTK Inhibitor Resistance

Introduction:

BTK (Bruton’s tyrosine kinase) inhibitors have shown great promise in the treatment of B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). However, resistance to BTK inhibitors has emerged as a significant clinical challenge, limiting their long-term efficacy. This thesis aims to explore novel approaches to overcome BTK inhibitor resistance and improve the outcomes of patients with B-cell malignancies.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review

2.1 Overview of BTK inhibitors
2.2 Mechanisms of BTK inhibitor resistance
2.3 Current strategies to overcome BTK inhibitor resistance
2.4 Targeted therapies in B-cell malignancies
2.5 Immunotherapy approaches in B-cell malignancies
2.6 Combination therapies with BTK inhibitors
2.7 Emerging therapies for B-cell malignancies
2.8 Biomarkers for predicting BTK inhibitor response
2.9 Clinical implications of BTK inhibitor resistance
2.10 Future directions in overcoming BTK inhibitor resistance

Chapter 3: Research Methodology

3.1 Study design
3.2 Population and sample selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Research limitations
3.7 Validation of results
3.8 Statistical analysis

Chapter 4: Discussion of Findings

4.1 Analysis of data
4.2 Comparison of novel approaches to overcome BTK inhibitor resistance
4.3 Clinical implications of findings
4.4 Limitations of the study
4.5 Future research directions

Chapter 5: Conclusion and Summary

5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

This thesis will provide valuable insights into novel approaches to overcome BTK inhibitor resistance and contribute to the development of more effective treatment strategies for patients with B-cell malignancies.

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