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Introduction

Stroke is a leading cause of morbidity and mortality worldwide, with a significant burden on healthcare systems. Anticoagulants are commonly used to prevent stroke in patients with atrial fibrillation, a major risk factor for stroke. Traditional anticoagulants such as warfarin have been effective in preventing stroke, but they have limitations such as a narrow therapeutic window, frequent monitoring requirements, and potential drug interactions. Novel anticoagulants have been developed to overcome these limitations and provide safer and more convenient options for stroke prevention.

This thesis aims to explore the efficacy and safety of novel anticoagulants for stroke prevention in patients with atrial fibrillation. The study will investigate the current landscape of anticoagulant therapy for stroke prevention, the challenges faced by traditional anticoagulants, and how novel anticoagulants are addressing these challenges. The research will also examine the impact of novel anticoagulants on patient outcomes and healthcare costs.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of stroke and atrial fibrillation
2.2 Current anticoagulant therapy for stroke prevention
2.3 Limitations of traditional anticoagulants
2.4 Development and mechanism of action of novel anticoagulants
2.5 Clinical trials and real-world studies on novel anticoagulants
2.6 Comparisons between novel and traditional anticoagulants
2.7 Adherence and persistence with novel anticoagulants
2.8 Safety and bleeding risk with novel anticoagulants
2.9 Cost-effectiveness of novel anticoagulants
2.10 Future directions in anticoagulant therapy for stroke prevention

Chapter 3: Research Methodology
3.1 Study design
3.2 Selection of study population
3.3 Data collection methods
3.4 Statistical analysis
3.5 Ethical considerations
3.6 Validity and reliability of data
3.7 Limitations of the study
3.8 Timeline and budget for the study

Chapter 4: Discussion of Findings
4.1 Efficacy of novel anticoagulants for stroke prevention
4.2 Safety profile of novel anticoagulants
4.3 Impact on patient outcomes
4.4 Healthcare utilization and costs
4.5 Adherence and persistence with novel anticoagulants
4.6 Comparative effectiveness of novel versus traditional anticoagulants
4.7 Factors influencing provider prescribing and patient acceptance
4.8 Policy implications for the use of novel anticoagulants

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

Thesis Overview: Novel Anticoagulants for Stroke Prevention

Stroke is a major public health concern globally, and atrial fibrillation is a significant risk factor for stroke. Anticoagulants have been the cornerstone of stroke prevention in patients with atrial fibrillation, but traditional anticoagulants such as warfarin have limitations that have led to the development of novel anticoagulants. This thesis aims to evaluate the efficacy, safety, and cost-effectiveness of novel anticoagulants for stroke prevention in patients with atrial fibrillation.

The literature review will provide an overview of stroke and atrial fibrillation, current anticoagulant therapy, the limitations of traditional anticoagulants, the development and mechanism of action of novel anticoagulants, and comparisons between novel and traditional anticoagulants. The research methodology will outline the study design, selection of study population, data collection methods, statistical analysis, ethical considerations, and limitations of the study.

The discussion of findings will focus on the efficacy and safety of novel anticoagulants, their impact on patient outcomes and healthcare costs, adherence and persistence with novel anticoagulants, comparative effectiveness with traditional anticoagulants, and factors influencing provider prescribing and patient acceptance. The conclusion will summarize key findings, provide implications for clinical practice, recommendations for future research, and a conclusion on the use of novel anticoagulants for stroke prevention.

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