Introduction:

Traumatic brain injury (TBI) is a significant health issue worldwide, with millions of cases reported each year. One of the key mechanisms involved in the pathophysiology of TBI is neurovascular coupling, which refers to the close interaction between neuronal activity and cerebral blood flow regulation. Understanding the complex relationship between neurons and blood vessels in the brain following TBI is crucial for developing effective treatment strategies and improving patient outcomes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Neurophysiology of traumatic brain injury
2.2 Neurovascular coupling in healthy brain
2.3 Dysregulation of neurovascular coupling in TBI
2.4 Imaging techniques for studying neurovascular coupling
2.5 Therapeutic approaches targeting neurovascular coupling in TBI
2.6 Animal models of neurovascular coupling in TBI
2.7 Clinical studies on neurovascular coupling in TBI
2.8 Neuroinflammation and its impact on neurovascular coupling in TBI
2.9 Genetic factors influencing neurovascular coupling in TBI
2.10 Future directions in the study of neurovascular coupling in TBI

Chapter 3: Research Methodology
3.1 Study design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Neuroimaging protocols
3.6 Biomarker analysis
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Neurovascular coupling alterations in TBI patients
4.2 Relationship between neurovascular coupling dysfunction and clinical outcomes
4.3 Mechanisms underlying neurovascular coupling dysregulation in TBI
4.4 Comparison of neurovascular coupling in mild, moderate, and severe TBI
4.5 Impact of neuroinflammation on neurovascular coupling in TBI
4.6 Therapeutic implications of targeting neurovascular coupling in TBI
4.7 Future research directions

Chapter 5: Conclusion and Summary
In this final chapter, the key findings of the study will be summarized, and the implications for clinical practice and future research will be discussed.

Thesis Overview:

Neurovascular coupling in traumatic brain injury is a complex and multifaceted phenomenon that plays a crucial role in the pathophysiology of TBI. This thesis aims to provide a comprehensive overview of the current understanding of neurovascular coupling in TBI, including its dysregulation following injury, imaging methods for studying it, and potential therapeutic interventions targeting this mechanism.

The literature review will encompass neurophysiological aspects of TBI, the normal functioning of neurovascular coupling in the healthy brain, and the alterations seen in TBI. Various imaging techniques used to study neurovascular coupling will be discussed, along with animal models and clinical studies examining this phenomenon. Additionally, the impact of neuroinflammation and genetic factors on neurovascular coupling in TBI will be explored.

The research methodology section will outline the study design, participant selection, data collection and analysis methods, as well as neuroimaging protocols and ethical considerations. The discussion of findings will present the results of the study, examining the alterations in neurovascular coupling in TBI patients, their clinical implications, underlying mechanisms, and potential therapeutic strategies.

In conclusion, this thesis aims to shed light on the importance of neurovascular coupling in TBI and its potential as a therapeutic target for improving outcomes in TBI patients. By enhancing our understanding of this mechanism, we can develop more effective treatment approaches and ultimately improve the quality of life for individuals with TBI.

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