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Introduction

Migraine is a chronic neurological disorder characterized by recurrent episodes of severe headache, often accompanied by nausea, vomiting, and sensitivity to light and sound. It affects approximately 1 billion people worldwide and is a leading cause of disability. Neurovascular coupling, the process by which changes in neuronal activity are coupled to changes in cerebral blood flow, has been implicated in the pathophysiology of migraine. Understanding the mechanisms underlying neurovascular coupling in migraine may lead to the development of more effective treatments for this debilitating condition.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of migraine
2.2 Neurovascular coupling in normal physiology
2.3 Dysfunction of neurovascular coupling in migraine
2.4 Role of genetics in neurovascular coupling in migraine
2.5 Imaging techniques used to study neurovascular coupling in migraine
2.6 Pharmacological interventions targeting neurovascular coupling in migraine
2.7 Non-pharmacological interventions targeting neurovascular coupling in migraine
2.8 Comorbidities associated with aberrant neurovascular coupling in migraine
2.9 Gender differences in neurovascular coupling in migraine
2.10 Future directions in research on neurovascular coupling in migraine

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant selection
3.3 Data collection
3.4 Data analysis
3.5 Statistical methods
3.6 Ethical considerations
3.7 Limitations of the study
3.8 Future research directions

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Comparison with existing literature
4.3 Implications for clinical practice
4.4 Limitations of the study
4.5 Strengths of the study
4.6 Future research directions
4.7 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Contribution to the field
5.3 Implications for clinical practice
5.4 Recommendations for future research
5.5 Concluding remarks

Thesis Overview on Neurovascular Coupling in Migraine

Migraine is a complex neurological disorder that affects a significant portion of the global population. The underlying mechanisms of migraine pathophysiology are still not fully understood, but there is growing evidence to suggest that neurovascular coupling plays a crucial role in the development and progression of migraine attacks. This thesis aims to explore the relationship between neurovascular coupling and migraine, with a focus on understanding the mechanisms involved, identifying potential treatment targets, and exploring the impact of gender and genetics on neurovascular coupling in migraine.

Chapter 1 provides an introduction to the topic, including background information on migraine, the problem statement, objectives of the study, limitations, scope, significance, and a definition of key terms. Chapter 2 offers a comprehensive review of the existing literature on neurovascular coupling in migraine, highlighting current research findings, gaps in knowledge, and potential future research directions. Chapter 3 details the research methodology employed in this study, including study design, participant selection, data collection and analysis, ethical considerations, limitations, and recommendations for future research.

Chapter 4 presents a detailed discussion of the findings from the study, including comparisons with existing literature, implications for clinical practice, limitations, strengths, and suggestions for further research. Finally, Chapter 5 offers a conclusion and summary of the thesis, summarizing the key findings, their implications, recommendations for future research, and concluding remarks.

Overall, this thesis aims to contribute to the growing body of knowledge on neurovascular coupling in migraine and provide insights that may lead to improved treatments and management strategies for individuals suffering from this debilitating condition.

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