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Introduction

Neurovascular coupling refers to the intricate relationship between neuronal activity and cerebral blood flow regulation, essential for maintaining optimal brain function. Cognitive aging, the natural decline in cognitive abilities over time, has been linked to alterations in neurovascular coupling mechanisms. Understanding the mechanisms underlying neurovascular coupling in cognitive aging is crucial for developing interventions to mitigate age-related cognitive decline.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Neurovascular coupling and cognitive function
2.2 Aging-related changes in neurovascular coupling
2.3 Neuroimaging techniques in studying neurovascular coupling
2.4 Impact of cardiovascular health on neurovascular coupling
2.5 Role of genetic factors in neurovascular coupling
2.6 Neuroinflammation and neurovascular dysfunction in aging
2.7 Neurovascular coupling and neurodegenerative diseases
2.8 Pharmacological interventions targeting neurovascular coupling
2.9 Non-pharmacological interventions for improving neurovascular coupling
2.10 Future directions in research on neurovascular coupling in cognitive aging

Chapter 3: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection methods
3.4 Neuroimaging protocols
3.5 Data analysis procedures
3.6 Ethical considerations
3.7 Validity and reliability
3.8 Limitations of the methodology

Chapter 4: Discussion of Findings
4.1 Neurovascular coupling changes in cognitive aging
4.2 Factors influencing neurovascular coupling in aging
4.3 Implications for cognitive function
4.4 Comparisons with previous research
4.5 Theoretical implications
4.6 Practical applications
4.7 Future research directions
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Contributions to the field
5.3 Implications for practice
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview:

Neurovascular coupling refers to the relationship between neuronal activity and cerebral blood flow regulation, essential for maintaining optimal brain function. With advancing age, this vital mechanism may become disrupted, leading to cognitive decline. The aim of this thesis is to explore the changes in neurovascular coupling associated with cognitive aging and investigate potential interventions to improve these processes.

Chapter 1 provides an introduction to the study, outlining the background, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter 2 presents a comprehensive literature review on neurovascular coupling, aging-related changes, neuroimaging techniques, cardiovascular health impact, genetic factors, neuroinflammation, pharmacological interventions, and future research directions.

In Chapter 3, the research methodology is detailed, including the design, participant selection, data collection methods, neuroimaging protocols, data analysis procedures, ethical considerations, and limitations. Chapter 4 discusses the findings of the study, focusing on neurovascular coupling changes in cognitive aging, influencing factors, implications for cognitive function, theoretical implications, practical applications, and recommendations for future research.

Finally, Chapter 5 presents the conclusion and summary of the thesis, summarizing the findings, discussing contributions to the field, implications for practice, recommendations for future research, and concluding remarks. This comprehensive exploration of neurovascular coupling in cognitive aging aims to contribute valuable insights to the field and guide future research endeavors in addressing age-related cognitive decline.

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