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Introduction

Neurovascular coupling refers to the phenomenon in which changes in neural activity are accompanied by changes in cerebral blood flow. This process is essential for maintaining overall brain function, as it ensures that neurons receive adequate oxygen and nutrients during increased activity. Alzheimerʼs disease is a neurodegenerative disorder characterized by the accumulation of amyloid-beta plaques and neurofibrillary tangles in the brain, leading to cognitive decline and memory loss.

Understanding the relationship between neurovascular coupling and Alzheimerʼs disease is crucial for developing effective treatment strategies and interventions. This thesis aims to explore the mechanisms underlying neurovascular coupling in Alzheimerʼs disease and investigate how alterations in this process contribute to the pathogenesis of the disease.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Alzheimerʼs disease
2.2 Neurovascular coupling in healthy individuals
2.3 Impairments in neurovascular coupling in neurodegenerative diseases
2.4 Role of amyloid-beta in neurovascular dysfunction
2.5 Neuroinflammation and neurovascular coupling
2.6 Imaging techniques for studying neurovascular coupling
2.7 Pharmacological interventions targeting neurovascular dysfunction
2.8 Genetic factors influencing neurovascular coupling
2.9 Behavioral and lifestyle factors affecting neurovascular coupling
2.10 Future directions in neurovascular research

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Study limitations
3.7 Validity and reliability of findings
3.8 Data interpretation

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Relationship between neurovascular coupling and Alzheimerʼs disease
4.3 Implications for clinical practice
4.4 Comparison with existing literature
4.5 Strengths and limitations of the study
4.6 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for practice
5.4 Recommendations for future research

Thesis Overview

Neurovascular coupling plays a critical role in maintaining brain function by ensuring that neurons receive adequate oxygen and nutrients during periods of increased activity. In Alzheimerʼs disease, disruptions in neurovascular coupling have been implicated in the pathogenesis of the disease, leading to cognitive decline and memory impairment. This thesis aims to investigate the mechanisms underlying neurovascular coupling in Alzheimerʼs disease and explore potential interventions to target these disruptions.

The literature review will provide an overview of Alzheimerʼs disease, neurovascular coupling in healthy individuals, impairments in neurovascular coupling in neurodegenerative diseases, and the role of amyloid-beta in neurovascular dysfunction. Additionally, the research methodology section will outline the study design, participant recruitment, data collection methods, and data analysis techniques.

The discussion of findings will examine the relationship between neurovascular coupling and Alzheimerʼs disease, discuss the implications for clinical practice, and compare the findings with existing literature. The conclusion will summarize the key findings, highlight the contributions to the field, and make recommendations for future research in this area. By shedding light on the role of neurovascular coupling in Alzheimerʼs disease, this thesis aims to provide valuable insights for the development of targeted interventions and treatment strategies for this devastating neurodegenerative disorder.

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