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Introduction

Working memory is a fundamental cognitive function that allows individuals to temporarily store and manipulate information for tasks such as reasoning, problem-solving, and decision-making. It is well-established that working memory capacity declines with age, leading to cognitive impairments in older adults. Neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), have been used to investigate the neural mechanisms underlying working memory in aging.

This thesis aims to review the current literature on neuroimaging studies of working memory in aging, with a focus on the structural and functional changes in the brain associated with age-related cognitive decline. The findings of this thesis will contribute to our understanding of the neural basis of working memory deficits in older adults and may inform the development of interventions to support cognitive health in aging populations.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of working memory
2.2 Neuroimaging techniques
2.3 Aging and cognitive decline
2.4 Structural changes in the aging brain
2.5 Functional changes in the aging brain
2.6 Neural correlates of working memory in aging
2.7 Cognitive interventions in aging
2.8 Neuroimaging studies of working memory in aging
2.9 Gaps in the literature
2.10 Summary of the literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Neuroimaging measures
3.4 Data analysis
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Data collection procedure
3.8 Pilot study
3.9 Limitations of the study

Chapter 4: Discussion of Findings
4.1 Overview of the findings
4.2 Structural changes in the aging brain
4.3 Functional changes in the aging brain
4.4 Neural correlates of working memory in aging
4.5 Implications for cognitive interventions
4.6 Comparison with previous studies
4.7 Future directions
4.8 Strengths and limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of findings
5.2 Contributions to the field
5.3 Implications for future research
5.4 Practical applications
5.5 Conclusion

This thesis will provide a comprehensive overview of the current state of knowledge on neuroimaging of working memory in aging, including a critical analysis of the existing literature, a detailed description of the research methodology, a discussion of the findings, and implications for future research and clinical practice. The significance of this study lies in its potential to advance our understanding of age-related changes in working memory and inform the development of evidence-based interventions to support cognitive health in older adults.

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