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Introduction

Alzheimer’s disease is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Early detection of Alzheimer’s disease is crucial for timely intervention and management of the disease. Neuroimaging techniques have emerged as promising tools for identifying biomarkers that can aid in the early detection of Alzheimer’s disease. These biomarkers can provide valuable insights into the underlying pathology of the disease and help in monitoring disease progression. This thesis aims to explore the potential of neuroimaging biomarkers for early detection of Alzheimer’s disease.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Alzheimer’s disease
2.2 Neuroimaging techniques in Alzheimer’s disease
2.3 Structural MRI biomarkers
2.4 Functional MRI biomarkers
2.5 Positron emission tomography (PET) biomarkers
2.6 Diffusion tensor imaging (DTI) biomarkers
2.7 Magnetic resonance spectroscopy (MRS) biomarkers
2.8 Challenges in neuroimaging biomarkers for Alzheimer’s disease
2.9 Current research in neuroimaging biomarkers for early detection
2.10 Gaps in literature

Chapter 3: Research Methodology
3.1 Research design
3.2 Participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Neuroimaging protocols
3.6 Study variables
3.7 Ethical considerations
3.8 Limitations of research methodology

Chapter 4: Discussion of Findings
4.1 Overview of study findings
4.2 Relationship between neuroimaging biomarkers and Alzheimer’s disease
4.3 Predictive value of neuroimaging biomarkers
4.4 Implications for early detection and intervention
4.5 Comparison with other biomarkers
4.6 Future directions for research
4.7 Clinical implications
4.8 Recommendations for practice

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Limitations of the study
5.4 Implications for future research
5.5 Conclusion

Thesis Overview

Alzheimer’s disease is a growing concern in the aging population, with the need for early detection becoming increasingly important. Neuroimaging techniques offer a non-invasive and potentially powerful tool for identifying biomarkers associated with Alzheimer’s disease. This thesis aims to explore the current research in neuroimaging biomarkers for early detection of Alzheimer’s disease, with a focus on the potential implications for clinical practice.

The literature review will provide an overview of Alzheimer’s disease, neuroimaging techniques commonly used in research, and the challenges and gaps in current research. The research methodology section will outline the study design, data collection methods, and analysis techniques used in the thesis. The discussion of findings will present the key results and implications of the research, while the conclusion will summarize the findings and suggest directions for future research.

Overall, this thesis seeks to contribute to the growing body of knowledge on neuroimaging biomarkers for early detection of Alzheimer’s disease, with the ultimate goal of improving diagnostic accuracy and patient outcomes in clinical practice.

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