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Introduction

Major depressive disorder (MDD) is a common and debilitating mental health condition that affects millions of people worldwide. Despite decades of research, the underlying causes of MDD remain unclear, with both genetic and environmental factors thought to play a role in its development. In recent years, the field of neurogenetics has emerged as a promising area of study, focusing on the genetic underpinnings of neurological and psychiatric disorders, including MDD.

This thesis aims to explore the neurogenetic factors that contribute to MDD, with a focus on understanding the genetic mechanisms that may increase susceptibility to the disorder. By investigating the genetic basis of MDD, we hope to gain a better understanding of its pathophysiology and potentially identify new targets for treatment and intervention.

Chapter One: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
2.1 Overview of Major Depressive Disorder
2.2 Neurogenetics of Major Depressive Disorder
2.3 Genetic Risk Factors for MDD
2.4 Environmental Influences on MDD
2.5 Gene-Environment Interactions in MDD
2.6 Neurobiological Pathways Implicated in MDD
2.7 Pharmacogenetics of Antidepressant Response
2.8 Neuroimaging Studies in MDD
2.9 Epigenetic Mechanisms in MDD
2.10 Future Directions in Neurogenetics Research

Chapter Three: Research Methodology
3.1 Research Design
3.2 Participant Recruitment and Selection
3.3 Data Collection Methods
3.4 Genetic Analysis Techniques
3.5 Statistical Analysis Plan
3.6 Ethical Considerations
3.7 Quality Control Measures
3.8 Data Interpretation and Reporting

Chapter Four: Discussion of Findings
4.1 Genetic Variants Associated with MDD
4.2 Gene-Environment Interactions
4.3 Epigenetic Modifications in MDD
4.4 Neurobiological Pathways Implicated in MDD
4.5 Implications for Treatment and Intervention
4.6 Limitations of the Study
4.7 Future Directions for Research

Chapter Five: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Clinical Practice
5.3 Recommendations for Future Research
5.4 Conclusion

Thesis Overview

Major depressive disorder (MDD) is a complex and multifactorial mental health condition that affects millions of individuals worldwide. Despite the availability of various treatment options, a significant proportion of individuals with MDD do not achieve remission with current therapies. The field of neurogenetics has provided valuable insights into the genetic basis of MDD, with a growing body of evidence suggesting that genetic factors play a significant role in the etiology of the disorder.

This thesis aims to review the current literature on the neurogenetics of MDD, with a focus on understanding the genetic risk factors, gene-environment interactions, and epigenetic modifications associated with the disorder. By examining the genetic underpinnings of MDD, we hope to identify potential biomarkers for the disorder, as well as new targets for treatment and intervention.

Through a comprehensive review of the literature, this thesis aims to provide a deeper understanding of the genetic mechanisms underlying MDD and their implications for clinical practice. Additionally, by outlining the research methodology and discussing the findings of the study, this thesis seeks to contribute to the growing body of evidence on the neurogenetics of MDD and provide recommendations for future research in this field.

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