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Introduction
Major depressive disorder (MDD) is a serious mental illness that affects millions of people worldwide. It is characterized by persistent feelings of sadness, hopelessness, and loss of interest in daily activities. While the exact cause of MDD is unknown, research has shown that abnormalities in neurogenesis, the process by which new neurons are formed in the brain, may play a significant role in the development of the disorder. This thesis aims to explore the relationship between neurogenesis and MDD, with the goal of better understanding the underlying mechanisms of the disorder and potentially developing new treatment strategies.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
– Overview of Major Depressive Disorder
– Neurobiology of Major Depressive Disorder
– Neurogenesis and its Role in MDD
– Current Treatment Strategies for MDD
– Animal Models of MDD and Neurogenesis
– Neurotrophic Factors and MDD
– Stress and its Impact on Neurogenesis
– Genetic Factors in Neurogenesis and MDD
– Neuroinflammation and MDD
– Relationship between Neurogenesis and Antidepressant Response

Chapter 3: Research Methodology
– Research Design
– Sample Selection
– Data Collection Methods
– Data Analysis Techniques
– Ethical Considerations
– Validity and Reliability
– Limitations of the Study
– Future Research Directions

Chapter 4: Discussion of Findings
– Overview of Study Results
– Comparison with Existing Literature
– Implications for Clinical Practice
– Limitations of the Study
– Recommendations for Future Research

Chapter 5: Conclusion and Summary
– Summary of Key Findings
– Conclusions drawn from the Study
– Practical Implications
– Recommendations for Clinical Practice
– Suggestions for Future Research

Thesis Overview on Neurogenesis in Major Depressive Disorder
Major depressive disorder (MDD) is a debilitating mental illness that affects millions of individuals worldwide. The exact cause of MDD is not yet fully understood, but research suggests that abnormalities in neurogenesis, the process by which new neurons are formed in the brain, may play a significant role in the development of the disorder. This thesis aims to investigate the relationship between neurogenesis and MDD, with the goal of elucidating the underlying mechanisms of the disorder and potentially identifying new treatment approaches.

Chapter one provides an introduction to the topic, including background information on MDD, the problem statement, objectives of the study, limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter two reviews the existing literature on MDD, neurogenesis, current treatment strategies, animal models, neurotrophic factors, stress, genetic factors, neuroinflammation, and the relationship between neurogenesis and antidepressant response.

Chapter three details the research methodology, including research design, sample selection, data collection methods, analysis techniques, ethical considerations, validity and reliability, limitations, and future research directions. Chapter four discusses the findings of the study, including an overview of results, comparisons with existing literature, implications for clinical practice, limitations, and recommendations for future research.

In chapter five, the thesis concludes by summarizing key findings, drawing conclusions from the study, discussing practical implications, providing recommendations for clinical practice, and suggesting areas for future research. This thesis aims to contribute to the growing body of knowledge on the role of neurogenesis in MDD and provide insights that may lead to improved treatment strategies for individuals suffering from this debilitating disorder.

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