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Introduction

The discovery and development of antibiotics have revolutionized modern medicine, significantly reducing morbidity and mortality rates associated with infectious diseases. However, the emergence of antibiotic-resistant bacteria poses a significant threat to public health, highlighting the urgent need for the discovery of new antibiotics. Natural products have historically served as a rich source of bioactive compounds, including antibiotics. The purpose of this thesis is to explore the potential of natural products as a source of new antibiotics.

Chapter 1: Introduction

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review

2.1 Historical perspective on antibiotics
2.2 Antibiotic resistance
2.3 Natural products as a source of antibiotics
2.4 Methods for discovering new antibiotics from natural products
2.5 Bioactivity screening of natural products
2.6 Case studies of natural products-derived antibiotics
2.7 Challenges and opportunities in natural products drug discovery
2.8 Regulatory considerations for natural products-derived antibiotics
2.9 Future perspectives on natural products as a source of new antibiotics

Chapter 3: Research Methodology

3.1 Research design
3.2 Sampling strategy
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Bioactivity screening assays
3.6 Isolation and structural elucidation of bioactive compounds
3.7 In vitro and in vivo antimicrobial activity testing
3.8 Safety and toxicity assessment of potential antibiotics

Chapter 4: Discussion of Findings

4.1 Identification of bioactive compounds from natural products
4.2 Antimicrobial activity of bioactive compounds
4.3 Mechanism of action of potential antibiotics
4.4 Synergistic effects of natural products-derived antibiotics
4.5 Comparison with existing antibiotics
4.6 Potential for antibiotic resistance development
4.7 Safety and toxicity profile of new antibiotics
4.8 Implications for clinical use
4.9 Future research directions

Chapter 5: Conclusion and Summary

In conclusion, natural products represent a valuable source of new antibiotics with the potential to address the growing threat of antibiotic resistance. This thesis aims to contribute to the field of natural products drug discovery by exploring the diversity of bioactive compounds found in nature and their potential applications as new antibiotics. By leveraging the rich chemical diversity of natural products, researchers can harness the power of nature to combat infectious diseases and improve public health outcomes.

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