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Introduction

Psoriasis is a chronic immune-mediated inflammatory skin disease that affects millions of people worldwide. Despite extensive research, the exact etiology and pathogenesis of psoriasis remain unclear. Metabolomics, a rapidly evolving field in systems biology, offers a powerful approach to study the metabolic perturbations associated with psoriasis. By analyzing the complex network of small molecules within biological samples, metabolomics can provide valuable insights into the biochemical pathways involved in the pathogenesis of psoriasis.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Psoriasis
2.2 Current Understanding of Psoriasis Pathogenesis
2.3 Metabolomics: Principles and Techniques
2.4 Metabolomics Studies in Dermatological Diseases
2.5 Metabolomic Biomarkers in Psoriasis
2.6 Metabolomics Approaches in Psoriasis Research
2.7 Integration of Metabolomics with Other Omics Technologies
2.8 Challenges and Limitations of Metabolomics in Psoriasis Research
2.9 Future Directions in Metabolomics of Psoriasis

Chapter 3: Research Methodology
3.1 Study Design
3.2 Patient Recruitment and Sample Collection
3.3 Metabolomic Profiling
3.4 Data Processing and Analysis
3.5 Statistical Analysis
3.6 Pathway Analysis
3.7 Validation Studies
3.8 Ethical Considerations

Chapter 4: Discussion of Findings
4.1 Metabolic Profiles in Psoriasis Patients
4.2 Identification of Metabolic Biomarkers
4.3 Pathway Analysis of Metabolic Pathways
4.4 Comparison with Existing Literature
4.5 Implications for Psoriasis Pathogenesis
4.6 Potential Therapeutic Targets
4.7 Future Research Directions

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Contributions to Psoriasis Research
5.3 Limitations of the Study
5.4 Recommendations for Future Research
5.5 Conclusion

Thesis Overview on Metabolomics of Psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation of keratinocytes and immune dysregulation. Despite numerous studies, the exact molecular mechanisms underlying psoriasis pathogenesis remain incompletely understood. Metabolomics, an emerging technology in systems biology, offers a comprehensive approach to unravel the metabolic alterations associated with psoriasis. By analyzing the small molecule profiles in biological samples, metabolomics can provide crucial insights into the biochemical pathways involved in the pathogenesis of psoriasis.

The aim of this thesis is to investigate the metabolomic profiles of patients with psoriasis and identify potential metabolic biomarkers for disease diagnosis and monitoring. The study will involve the collection of biological samples from psoriasis patients and healthy controls, followed by metabolomic profiling using advanced analytical techniques. The data generated will be analyzed using bioinformatics tools to identify significant metabolic changes associated with psoriasis. Pathway analysis will be conducted to elucidate the underlying metabolic pathways dysregulated in the disease.

The research methodology will include a detailed description of the study design, patient recruitment, sample collection, metabolomic profiling, data processing, statistical analysis, and validation studies. Ethical considerations will also be discussed to ensure the protection of patient rights and confidentiality. The findings of the study will be critically discussed in the context of existing literature, highlighting the novel insights provided by metabolomics in psoriasis research.

In conclusion, this thesis will contribute to the growing body of knowledge on the metabolomics of psoriasis and pave the way for future research in this field. The identification of metabolic biomarkers and dysregulated pathways in psoriasis may lead to the development of targeted therapies and personalized treatment approaches for patients with this debilitating skin disease.

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