Mechanisms of neurodegeneration in Huntingtonʼs disease – Complete Phd and Masters Thesis

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Introduction:

Neurodegenerative diseases are a major public health concern worldwide, with Huntingtonʼs disease (HD) being a particularly devastating condition. HD is a genetic disorder that leads to the progressive degeneration of nerve cells in the brain, resulting in a range of physical, cognitive, and psychiatric symptoms. Despite extensive research efforts, the exact mechanisms underlying neurodegeneration in HD remain poorly understood. This thesis aims to investigate the mechanisms of neurodegeneration in HD, with a focus on identifying potential targets for therapeutic intervention.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Huntingtonʼs disease
2.2 Genetic basis of HD
2.3 Pathophysiology of HD
2.4 Molecular mechanisms of neurodegeneration
2.5 Mitochondrial dysfunction in HD
2.6 Oxidative stress and HD
2.7 Excitotoxicity in HD
2.8 Inflammation in HD
2.9 Autophagy dysfunction in HD
2.10 Therapeutic strategies for HD

Chapter 3: Research Methodology
3.1 Research design
3.2 Participant selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Validity and reliability
3.7 Pilot study
3.8 Research limitations

Chapter 4: Discussion of Findings
4.1 Summary of findings
4.2 Comparison with existing literature
4.3 Implications for future research
4.4 Clinical relevance
4.5 Limitations of the study
4.6 Strengths of the study
4.7 Recommendations for practice
4.8 Conclusions

Chapter 5: Conclusion and Summary
In this chapter, the main findings of the study will be summarized and conclusions drawn. The implications of the research findings for the field of neurodegenerative diseases, particularly Huntingtonʼs disease, will be discussed. Recommendations for future research directions will also be provided.

Thesis Overview:

Huntingtonʼs disease (HD) is a devastating neurodegenerative disorder that affects thousands of people worldwide. Despite many years of research, the exact mechanisms underlying neurodegeneration in HD remain poorly understood. This thesis aims to investigate the mechanisms of neurodegeneration in HD, with a focus on identifying potential targets for therapeutic intervention.

Chapter 1 provides an introduction to the study, outlining the background, problem statement, objectives, limitations, scope, significance, structure, and definition of terms. Chapter 2 presents a comprehensive review of the literature on HD, covering aspects such as its genetic basis, pathophysiology, molecular mechanisms of neurodegeneration, and potential therapeutic strategies.

Chapter 3 details the research methodology, including the research design, participant selection, data collection methods, data analysis techniques, ethical considerations, validity, reliability, pilot study, and limitations. Chapter 4 discusses the findings of the study, comparing them with existing literature, exploring implications for future research, clinical relevance, study limitations, strengths, and recommendations for practice.

Chapter 5 provides a summary and conclusion, drawing together the main findings and discussing their implications for the field of neurodegenerative diseases. Recommendations for future research directions are also outlined. This thesis aims to contribute to our understanding of the mechanisms of neurodegeneration in Huntingtonʼs disease, with the ultimate goal of identifying new therapeutic targets to improve the lives of individuals affected by this devastating condition.

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