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Introduction

The repair of DNA interstrand crosslinks is a vital process that ensures the maintenance of genomic stability and integrity in all living organisms. DNA interstrand crosslinks are covalent bonds between the two strands of the DNA double helix, which can be induced by various endogenous and exogenous sources, such as reactive oxygen species, chemical agents, and ionizing radiation. Failure to repair these lesions can lead to genomic instability, cell death, and ultimately, cancer. Understanding the mechanisms involved in the repair of DNA interstrand crosslinks is essential for the development of novel therapeutic strategies for cancer treatment.

This thesis aims to explore the mechanisms of DNA interstrand crosslink repair, focusing on the various pathways and proteins involved in this process. By elucidating the intricate molecular mechanisms that govern DNA interstrand crosslink repair, we hope to uncover potential targets for the development of more effective cancer therapies.

Chapter One: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
2.1 DNA interstrand crosslinks: types and formation
2.2 Cellular responses to DNA interstrand crosslinks
2.3 DNA repair pathways involved in DNA interstrand crosslink repair
2.4 Proteins involved in DNA interstrand crosslink repair
2.5 Small molecule inhibitors of DNA interstrand crosslink repair
2.6 Clinical implications of DNA interstrand crosslink repair defects
2.7 Current challenges in DNA interstrand crosslink repair research
2.8 Future directions in DNA interstrand crosslink repair research
2.9 Summary of literature review
2.10 Gaps in the literature

Chapter Three: Research Methodology
3.1 Research design
3.2 Sample collection and preparation
3.3 Experimental procedures
3.4 Data analysis
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Quality control measures
3.8 Timeline and budget
3.9 Potential limitations
3.10 Conclusion

Chapter Four: Discussion of Findings
4.1 Overview of results
4.2 Comparison with existing literature
4.3 Implications of findings
4.4 Strengths and limitations of the study
4.5 Future research directions
4.6 Clinical relevance
4.7 Contribution to the field
4.8 Conclusion

Chapter Five: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for cancer therapy
5.3 Limitations of the study
5.4 Recommendations for future research
5.5 Conclusion

In conclusion, this thesis will provide a comprehensive overview of the mechanisms involved in DNA interstrand crosslink repair, shedding light on the potential avenues for targeting this process in cancer therapy. By elucidating the intricate molecular pathways that govern DNA interstrand crosslink repair, this research aims to contribute to the development of more effective and targeted cancer treatments.

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