[ad_1]

Introduction

Parkinson’s disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra region of the brain, leading to motor symptoms such as tremors, rigidity, and bradykinesia. In addition to motor symptoms, Parkinson’s disease is also associated with non-motor symptoms, including cognitive impairment and dementia. Parkinson’s disease dementia (PDD) affects up to 80% of patients with Parkinson’s disease, significantly impacting their quality of life and prognosis.

Recent research has highlighted the potential role of the gut microbiome in the development and progression of neurodegenerative diseases, including Parkinson’s disease. The gut-brain axis is a bidirectional communication system between the gastrointestinal tract and the central nervous system, involving neural, immune, and endocrine pathways. The gut microbiome, which refers to the community of microorganisms residing in the gastrointestinal tract, plays a crucial role in maintaining gut homeostasis and regulating various physiological functions, including immune system modulation, neurotransmitter production, and metabolic pathways.

Despite growing evidence linking the gut microbiome to neurodegenerative diseases, the specific mechanisms by which the gut microbiome influences the development of PDD remain poorly understood. This thesis aims to investigate the role of the gut microbiome in the pathogenesis of PDD, with a focus on elucidating the underlying molecular and cellular mechanisms involved.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Parkinson’s disease and Parkinson’s disease dementia
2.2 Gut-brain axis and the role of the gut microbiome in neurodegenerative diseases
2.3 Dysbiosis and alterations in the gut microbiome in Parkinson’s disease
2.4 Potential mechanisms linking the gut microbiome to cognitive impairment and dementia
2.5 Clinical studies investigating the gut microbiome in Parkinson’s disease dementia
2.6 Therapeutic interventions targeting the gut microbiome in neurodegenerative diseases
2.7 Animal models of Parkinson’s disease and gut microbiome research
2.8 Molecular and cellular pathways implicated in the gut-brain axis communication
2.9 Future directions for research on the gut microbiome and neurodegenerative diseases
2.10 Summary of key findings

Chapter 3: Research Methodology
3.1 Research design and rationale
3.2 Study population and sample selection
3.3 Data collection methods
3.4 Gut microbiome analysis techniques
3.5 Neurocognitive assessment tools
3.6 Statistical analysis plan
3.7 Ethical considerations
3.8 Timeline and budget

Chapter 4: Discussion of Findings
4.1 Gut microbiome composition in patients with Parkinson’s disease dementia
4.2 Correlation between gut microbiome diversity and cognitive impairment
4.3 Potential biomarkers of gut dysbiosis in PDD
4.4 Molecular pathways linking the gut microbiome to neurodegeneration
4.5 Implications for future research and clinical practice
4.6 Strengths and limitations of the study
4.7 Comparison with existing literature
4.8 Clinical relevance and practical implications

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for future research
5.4 Practical recommendations for healthcare providers
5.5 Concluding remarks

Thesis Overview

The gut microbiome has emerged as a key player in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease dementia (PDD). This thesis aims to investigate the role of the gut microbiome in the development of PDD by exploring the molecular and cellular mechanisms underlying the gut-brain axis communication. The literature review section provides a comprehensive overview of the current knowledge on Parkinson’s disease, the gut-brain axis, and the gut microbiome in neurodegenerative diseases, setting the stage for the research methodology and findings discussion.

The research methodology section outlines the study design, sample selection, data collection methods, gut microbiome analysis techniques, neurocognitive assessment tools, and statistical analysis plan. Ethical considerations, timeline, and budget are also discussed to ensure the study’s validity and reliability. The discussion of findings section presents the results of the study, including gut microbiome composition in PDD patients, correlations between gut dysbiosis and cognitive impairment, potential biomarkers of gut dysbiosis, and molecular pathways linking the gut microbiome to neurodegeneration.

The conclusion and summary section highlights the key findings of the study, contributions to the field, implications for future research, and practical recommendations for healthcare providers. By elucidating the role of the gut microbiome in PDD, this thesis aims to provide novel insights into the pathogenesis of neurodegenerative diseases and potential therapeutic targets for intervention.

[ad_2]

---

Purchase Detail

Download the complete project materials to this project with Abstract, Chapters 1 – 5, References and Appendix (Questionaire, Charts, etc), Click Here to place an order via whatsapp. Got question or enquiry; Click here to chat us up via Whatsapp.
You can also call 08111770269 or +2348059541956 to place an order or use the whatsapp button below to chat us up.
Bank details are stated below.

Bank: UBA
Account No: 1021412898
Account Name: Starnet Innovations Limited

The Blazingprojects Mobile App

Download and install the Blazingprojects Mobile App from Google Play to enjoy over 50,000 project topics and materials from 73 departments, completely offline (no internet needed) with monthly update to topics, click here to install.