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Introduction:

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that affects millions of people worldwide. Currently, there is no cure for MS, and available treatments only help manage the symptoms and slow down the progression of the disease. However, recent research has shown that exosome-based therapeutics may hold great promise for the treatment of MS. Exosomes are small extracellular vesicles that play a key role in intercellular communication and have been shown to have anti-inflammatory and neuroprotective properties. This thesis aims to investigate the potential of exosome-based therapeutics for the treatment of MS, with a focus on their ability to modulate the immune response and promote remyelination in the central nervous system.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of multiple sclerosis
2.2 Current treatment options for multiple sclerosis
2.3 Exosomes and their role in intercellular communication
2.4 Exosomes as potential therapeutics for neurological diseases
2.5 Animal models of multiple sclerosis
2.6 Studies on exosome-based therapeutics for multiple sclerosis
2.7 Mechanisms of action of exosome-based therapeutics
2.8 Challenges and limitations in the use of exosome-based therapeutics
2.9 Future directions in the field of exosome-based therapeutics
2.10 Summary of the literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Study population
3.3 Sample collection and processing
3.4 Isolation and characterization of exosomes
3.5 In vitro and in vivo experiments
3.6 Data analysis
3.7 Ethical considerations
3.8 Limitations of the research methodology

Chapter 4: Discussion of Findings
4.1 Characterization of exosomes isolated from different sources
4.2 In vitro effects of exosomes on immune cells
4.3 In vivo effects of exosomes in animal models of multiple sclerosis
4.4 Comparison of exosome-based therapeutics with conventional treatment options
4.5 Mechanisms of action of exosome-based therapeutics in the treatment of MS
4.6 Safety and toxicity of exosome-based therapeutics
4.7 Future directions for research in this field

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications of the findings for the treatment of multiple sclerosis
5.3 Recommendations for future research
5.4 Conclusion

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