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Thesis Overview

Title: Investigating the potential of exosome-based drug delivery systems for the treatment of Huntington’s disease

Introduction
Huntington’s disease is a neurodegenerative disorder characterized by the progressive loss of neurons in the brain, leading to motor dysfunction, cognitive impairment, and psychiatric symptoms. Current treatment options for Huntington’s disease are limited and focus primarily on managing symptoms rather than addressing the underlying cause of the disease. Exosome-based drug delivery systems have emerged as a promising approach for the treatment of neurodegenerative disorders, including Huntington’s disease. Exosomes are small extracellular vesicles that can cross the blood-brain barrier and deliver therapeutic cargo directly to the brain, making them an attractive option for targeted drug delivery. This thesis aims to investigate the potential of exosome-based drug delivery systems for the treatment of Huntington’s disease.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Huntington’s disease
2.2 Current treatment options for Huntington’s disease
2.3 Exosome biology and function
2.4 Exosome-based drug delivery systems
2.5 Exosome-mediated delivery of therapeutic cargo to the brain
2.6 Exosome-based therapies for neurodegenerative disorders
2.7 Challenges and limitations of exosome-based drug delivery systems
2.8 Strategies to enhance the therapeutic efficacy of exosome-based drug delivery systems
2.9 Preclinical studies investigating exosome-based therapies for Huntington’s disease
2.10 Clinical trials of exosome-based therapies for neurodegenerative disorders

Chapter 3: Research Methodology
3.1 Study design
3.2 Selection of exosome sources
3.3 Isolation and characterization of exosomes
3.4 Loading of therapeutic cargo into exosomes
3.5 Evaluation of exosome uptake by neuronal cells
3.6 Assessment of exosome-mediated delivery of therapeutic cargo to the brain
3.7 In vitro and in vivo models of Huntington’s disease
3.8 Data analysis

Chapter 4: Discussion of Findings
4.1 Efficacy of exosome-based drug delivery systems for the treatment of Huntington’s disease
4.2 Mechanisms of exosome-mediated delivery of therapeutic cargo to the brain
4.3 Comparison of different exosome sources for drug delivery
4.4 Optimization of exosome loading strategies
4.5 Challenges and limitations of exosome-based therapies for Huntington’s disease
4.6 Future directions for research on exosome-based drug delivery systems

Chapter 5: Conclusion and Summary
In conclusion, this thesis will provide valuable insights into the potential of exosome-based drug delivery systems for the treatment of Huntington’s disease. By investigating the efficacy and mechanisms of exosome-mediated delivery of therapeutic cargo to the brain, this research aims to contribute to the development of novel therapies for Huntington’s disease and other neurodegenerative disorders.

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