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Introduction

Rheumatoid arthritis is a chronic inflammatory autoimmune disease that affects millions of individuals worldwide. The hallmark of rheumatoid arthritis is inflammation of the synovium lining the joints, leading to joint destruction, pain, and disability. Anti-inflammatory drugs are commonly used in the management of rheumatoid arthritis to reduce inflammation and alleviate symptoms. However, the molecular mechanisms of action of these drugs in rheumatoid arthritis are not fully understood.

This thesis aims to investigate the molecular mechanisms of action of anti-inflammatory drugs in rheumatoid arthritis. By understanding how these drugs work at the molecular level, we can potentially identify new drug targets and improve current treatments for rheumatoid arthritis patients.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Rheumatoid Arthritis
2.2 Pathogenesis of Rheumatoid Arthritis
2.3 Current Treatments for Rheumatoid Arthritis
2.4 Anti-Inflammatory Drugs in Rheumatoid Arthritis
2.5 Molecular Targets of Anti-Inflammatory Drugs
2.6 Mechanisms of Action of Anti-Inflammatory Drugs
2.7 Resistance to Anti-Inflammatory Drugs
2.8 Combination Therapy in Rheumatoid Arthritis
2.9 Emerging Therapies in Rheumatoid Arthritis
2.10 Gaps in Knowledge

Chapter 3: Research Methodology
3.1 Study Design
3.2 Sample Collection
3.3 Cell Culture
3.4 Drug Treatment
3.5 Molecular and Cellular Assays
3.6 Data Analysis
3.7 Statistical Analysis
3.8 Ethical Considerations

Chapter 4: Discussion of Findings
4.1 Molecular Mechanisms of Anti-Inflammatory Drugs
4.2 Target Identification
4.3 Drug Resistance Mechanisms
4.4 Combination Therapy Strategies
4.5 Future Directions
4.6 Implications for Rheumatoid Arthritis Treatment

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Conclusions
5.3 Recommendations for Future Research
5.4 Practical Implications
5.5 Limitations of the Study

Overall, this thesis will provide valuable insights into the molecular mechanisms of action of anti-inflammatory drugs in rheumatoid arthritis, with the aim of improving treatment outcomes for patients with this debilitating disease.

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