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Introduction:

Drug resistance in HIV is a major challenge facing antiviral therapy worldwide. The ability of the virus to develop resistance to antiretroviral drugs hinders the effectiveness of treatment and poses a threat to global public health. Understanding the molecular mechanisms underlying drug resistance in HIV is crucial for developing strategies to overcome this problem and enhance the efficacy of antiviral therapy. This thesis aims to investigate the molecular basis of drug resistance in HIV and its implications for antiviral therapy.

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Introduction to drug resistance in HIV
2.2 Mechanisms of drug resistance in HIV
2.3 Impact of drug resistance on antiviral therapy
2.4 Current strategies for managing drug resistance
2.5 Molecular targets for overcoming drug resistance
2.6 Role of genotypic and phenotypic testing in drug resistance
2.7 Alternative therapies for drug-resistant HIV
2.8 Global perspectives on drug resistance in HIV
2.9 Future directions in research on drug resistance
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Sample selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Experimental procedures
3.6 Bioinformatics analysis
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Analysis of molecular mechanisms of drug resistance
4.2 Correlation between drug resistance mutations and treatment outcomes
4.3 Implications for personalized medicine in antiviral therapy
4.4 Potential strategies for overcoming drug resistance
4.5 Comparison of different approaches to managing drug resistance
4.6 Challenges and opportunities in drug resistance research
4.7 Recommendations for future research
4.8 Conclusion

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for antiviral therapy
5.3 Contributions to the field of HIV research
5.4 Limitations of the study
5.5 Recommendations for future research

Thesis Overview:

The emergence of drug resistance in HIV is a significant obstacle to successful antiviral therapy. This thesis aims to investigate the molecular basis of drug resistance in HIV and its implications for antiviral therapy. The literature review will provide a comprehensive overview of the current knowledge on drug resistance mechanisms, treatment outcomes, and strategies for managing resistance. The research methodology will detail the design and procedures for investigating drug resistance in HIV, including data collection, analysis, and ethical considerations. The discussion of findings will present the analysis of molecular mechanisms, correlation between mutations and treatment outcomes, implications for personalized medicine, and potential strategies for overcoming drug resistance. The conclusion will summarize key findings, implications for antiviral therapy, contributions to HIV research, limitations of the study, and recommendations for future research. This thesis is expected to contribute to understanding and addressing the challenges of drug resistance in HIV, ultimately improving the effectiveness of antiviral therapy for patients worldwide.

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