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Introduction:

Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms. It is caused by a mutation in the huntingtin gene, leading to the production of a mutant protein that forms toxic aggregates in the brain. Currently, there is no cure for HD, and available treatments only aim to alleviate symptoms and slow disease progression.

Recent studies have shown that the gut microbiome, the collection of microorganisms residing in the gastrointestinal tract, may play a role in the pathogenesis of neurodegenerative diseases, including HD. The gut-brain axis, a bidirectional communication system between the gut and the brain, has been implicated in the modulation of various physiological processes, including immune function, neurotransmitter production, and inflammation.

Understanding the influence of the gut microbiome on HD progression could provide novel insights into the disease mechanisms and potentially lead to new therapeutic strategies. This thesis aims to investigate the relationship between the gut microbiome and HD progression, with a specific focus on how alterations in gut microbial composition may impact disease pathology.

Table of Contents:

Chapter 1: Introduction
1.1 Introduction
1.2 Background of the study
1.3 Problem Statement
1.4 Objective of the study
1.5 Limitation of the study
1.6 Scope of the study
1.7 Significance of the study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of Huntington’s disease
2.2 Gut microbiome and neurodegenerative diseases
2.3 Gut-brain axis communication
2.4 Role of the gut microbiome in neuroinflammation
2.5 Gut microbiome dysbiosis in Huntington’s disease
2.6 Potential therapeutic interventions targeting the gut microbiome
2.7 Animal models of gut microbiome modulation in Huntington’s disease
2.8 Human studies investigating the gut microbiome in Huntington’s disease
2.9 Current gaps in knowledge
2.10 Summary of key findings

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant recruitment
3.3 Gut microbiome profiling
3.4 Clinical assessments
3.5 Statistical analysis
3.6 Ethical considerations
3.7 Data interpretation
3.8 Quality control measures

Chapter 4: Discussion of Findings
4.1 Gut microbiome composition in HD patients
4.2 Correlation between gut microbiome and disease severity
4.3 Potential mechanisms of gut-brain axis dysfunction in HD
4.4 Implications for future research
4.5 Limitations of the study
4.6 Comparison with existing literature
4.7 Clinical relevance
4.8 Future directions
4.9 Conclusions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for clinical practice
5.3 Recommendations for future research
5.4 Conclusion

With this structured approach, this thesis aims to provide a comprehensive understanding of the gut microbiome’s influence on Huntington’s disease progression and offer potential avenues for therapeutic intervention in the future.

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