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Introduction

Drug-induced liver injury (DILI) is a significant problem in clinical practice, as it can lead to acute liver failure and even death in severe cases. Understanding the molecular mechanisms underlying DILI is crucial for developing effective prevention and treatment strategies. Long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression and have been implicated in various physiological and pathological processes, including liver diseases. However, the role of lncRNAs in the regulation of DILI remains poorly understood. This thesis aims to explore the involvement of lncRNAs in the development and progression of DILI, shedding light on potential novel therapeutic targets for this condition.

Chapter One: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
2.1 Overview of Drug-induced liver injury
2.2 Long non-coding RNAs: Biogenesis and function
2.3 Role of lncRNAs in liver diseases
2.4 Mechanisms of DILI pathogenesis
2.5 Current treatment strategies for DILI
2.6 Studies investigating lncRNAs in DILI
2.7 Potential lncRNA targets for DILI therapy
2.8 Regulatory mechanisms of lncRNAs in DILI
2.9 Challenges and future directions in lncRNA research
2.10 Conclusion

Chapter Three: Research Methodology
3.1 Study design
3.2 Sample collection and processing
3.3 RNA extraction and sequencing
3.4 Bioinformatics analysis
3.5 Validation of lncRNA expression
3.6 Functional assays
3.7 Statistical analysis
3.8 Ethical considerations

Chapter Four: Discussion of Findings
4.1 Differential expression of lncRNAs in DILI patients
4.2 Functional characterization of candidate lncRNAs
4.3 Regulatory networks involving lncRNAs in DILI
4.4 Comparison with previous studies
4.5 Implications for DILI diagnosis and treatment
4.6 Limitations of the study
4.7 Future directions for research
4.8 Conclusion

Chapter Five: Conclusion
5.1 Summary of findings
5.2 Contribution to the field
5.3 Clinical implications
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview on Exploring the role of long non-coding RNAs in the regulation of drug-induced liver injury

This thesis aims to investigate the role of long non-coding RNAs (lncRNAs) in the regulation of drug-induced liver injury (DILI). Chapter One provides an introduction to the study, outlining the background, problem statement, objectives, scope, significance, and structure of the thesis. Chapter Two presents a comprehensive literature review on DILI, lncRNAs, their functions, and their potential role in liver diseases. Chapter Three details the research methodology, including study design, sample collection, RNA extraction, bioinformatics analysis, and validation techniques.

Chapter Four discusses the findings of the study, including the differential expression of lncRNAs in DILI patients, functional characterization of candidate lncRNAs, and regulatory networks involving lncRNAs in DILI. Chapter Five concludes the thesis by summarizing the findings, discussing their implications, and providing recommendations for future research in this field. Through this research, we aim to provide valuable insights into the molecular mechanisms underlying DILI and identify potential novel therapeutic targets for this condition.

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