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Introduction

Multiple sclerosis (MS) is a complex neurological disease characterized by the immune system attacking the central nervous system, leading to inflammation, demyelination, and neuronal degeneration. While genetic factors play a role in the development of MS, there is increasing evidence to suggest that epigenetic modifications also contribute to the pathogenesis of the disease. Epigenetic modifications refer to changes in gene expression that are not caused by alterations in the DNA sequence itself, but rather by modifications to DNA or histone proteins that can regulate gene activity.

This thesis aims to explore the role of epigenetic modifications in the development and progression of multiple sclerosis. By investigating how epigenetic changes influence the immune response, neuroinflammation, and neurodegeneration in MS, we hope to uncover new insights into the underlying mechanisms of the disease and identify potential therapeutic targets for intervention.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of multiple sclerosis
2.2 Genetic factors in MS
2.3 Epigenetic modifications in autoimmune diseases
2.4 DNA methylation in MS
2.5 Histone modifications in MS
2.6 Non-coding RNAs in MS
2.7 Epigenetic therapies in MS
2.8 Animal models of MS and epigenetics
2.9 Advances in epigenetic research in MS
2.10 Gaps in current knowledge

Chapter 3: Research Methodology
3.1 Study design
3.2 Participant selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Budget and timeline
3.7 Research limitations
3.8 Validation of findings

Chapter 4: Discussion of Findings
4.1 Epigenetic modifications in immune response in MS
4.2 Epigenetic changes in neuroinflammation in MS
4.3 Epigenetic regulation of neurodegeneration in MS
4.4 Comparison to previous studies
4.5 Implications for future research
4.6 Clinical relevance of findings
4.7 Potential therapeutic targets
4.8 Limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Future directions for research
5.4 Clinical implications
5.5 Conclusion

Thesis Overview

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system, leading to a wide range of debilitating symptoms. While the exact cause of MS remains unknown, both genetic and environmental factors are believed to contribute to its development. In recent years, there has been growing interest in the role of epigenetic modifications in MS, which can influence gene expression without altering the underlying DNA sequence.

This thesis aims to explore the role of epigenetic modifications in the development and progression of MS. By reviewing the current literature on epigenetics in MS, conducting original research on epigenetic changes in immune response, neuroinflammation, and neurodegeneration in MS, and discussing the implications of these findings for future research and clinical practice, this thesis seeks to advance our understanding of the molecular mechanisms underlying MS and identify potential targets for therapeutic intervention.

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