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Introduction

Malaria continues to be a major global health concern, with over 200 million cases reported each year. One of the biggest challenges in the treatment of malaria is the development of drug resistance by the parasite. Autophagy, a cellular process that degrades and recycles damaged organelles and proteins, has recently been implicated in the development of drug resistance in various diseases. However, its role in malaria drug resistance remains poorly understood.

This thesis aims to explore the role of autophagy in the development of drug resistance in malaria. By understanding the molecular mechanisms underlying this process, we hope to identify new targets for drug development and ultimately improve the efficacy of malaria treatment.

Chapter 1. Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2. Literature Review
2.1 Overview of malaria
2.2 Drug resistance in malaria
2.3 Autophagy: a cellular process
2.4 Autophagy in drug resistance
2.5 Role of autophagy in other diseases
2.6 Autophagy inhibitors
2.7 Autophagy inducers
2.8 Current treatment strategies for malaria
2.9 Autophagy and the immune system
2.10 Gaps in current knowledge

Chapter 3. Research Methodology
3.1 Study design
3.2 Sample collection
3.3 Data analysis
3.4 Molecular techniques
3.5 Cell culture methods
3.6 Drug sensitivity assays
3.7 Animal models
3.8 Ethical considerations

Chapter 4. Discussion of Findings
4.1 Autophagy in drug-resistant malaria strains
4.2 Molecular mechanisms of drug resistance
4.3 Autophagy inhibitors as potential treatment options
4.4 Autophagy inducers for overcoming resistance
4.5 Potential drug targets
4.6 Future directions for research
4.7 Implications for clinical practice
4.8 Limitations of the study

Chapter 5. Conclusion and Summary
5.1 Summary of findings
5.2 Conclusions
5.3 Recommendations for future research
5.4 Practical implications
5.5 Conclusion

Thesis Overview

Malaria remains a significant global health concern, with drug resistance posing a major obstacle to effective treatment. Autophagy, a cellular process involved in the degradation and recycling of cellular components, has been implicated in the development of drug resistance in various diseases. However, its role in malaria drug resistance is not well understood.

This thesis aims to explore the relationship between autophagy and drug resistance in malaria. Through a comprehensive review of the literature and a detailed research methodology, we will investigate the molecular mechanisms underlying this process and identify potential targets for therapeutic intervention.

By understanding the role of autophagy in malaria drug resistance, we hope to contribute to the development of new and more effective treatment strategies. This research has the potential to improve patient outcomes and reduce the global burden of malaria.

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