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Introduction

Drug repurposing, also known as drug repositioning or drug reprofiling, is the process of identifying new uses for existing drugs that are outside the scope of their original medical indications. This strategy has gained attention in recent years as a cost-effective approach to drug development, particularly for rare diseases where traditional drug discovery methods may be economically unfeasible. Rare diseases, also known as orphan diseases, affect a small percentage of the population and often have limited treatment options available. This thesis aims to explore the potential of drug repurposing as a viable strategy for the treatment of rare diseases.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of rare diseases
2.2 Current challenges in drug development for rare diseases
2.3 Drug repurposing as a strategy for rare diseases
2.4 Case studies of successful drug repurposing for rare diseases
2.5 Regulatory considerations for drug repurposing
2.6 Computational approaches to drug repurposing
2.7 Clinical trials and evidence-based medicine in drug repurposing
2.8 Ethical considerations in drug repurposing
2.9 Potential limitations and pitfalls of drug repurposing
2.10 Future directions and emerging trends in drug repurposing

Chapter 3: Research Methodology
3.1 Research design and approach
3.2 Data collection methods
3.3 Data analysis techniques
3.4 Study population and sample size
3.5 Inclusion and exclusion criteria
3.6 Ethical considerations
3.7 Statistical analysis plan
3.8 Validity and reliability assessment

Chapter 4: Discussion of Findings
4.1 Overview of findings
4.2 Comparison of drug repurposing strategies
4.3 Analysis of case studies
4.4 Implications for clinical practice
4.5 Recommendations for future research
4.6 Limitations of the study
4.7 Strengths of the study
4.8 Conclusions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Implications for practice
5.4 Recommendations for future research
5.5 Conclusion

Thesis Overview:

Drug repurposing for rare diseases has emerged as a promising strategy in the field of drug development, particularly for conditions with limited treatment options. This thesis aims to explore the potential of drug repurposing as a cost-effective and efficient approach to addressing the unmet medical needs of patients with rare diseases. The literature review will provide an overview of rare diseases, current challenges in drug development, and the role of drug repurposing in this context. The research methodology section will outline the design and approach of the study, data collection and analysis methods, and ethical considerations. The discussion of findings will present an analysis of case studies, implications for clinical practice, and recommendations for future research. The conclusion will summarize the key findings of the study and their contributions to the field, as well as provide recommendations for future research directions.

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