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Introduction

Liver diseases are a major public health concern worldwide, with conditions such as hepatitis, cirrhosis, and liver cancer affecting millions of people every year. Current treatments for these diseases are often limited in efficacy and can have significant side effects. Drug repositioning, the process of identifying new therapeutic uses for existing drugs, has emerged as a promising strategy for finding novel treatments for liver diseases. By repurposing drugs that are already approved for other indications, drug repositioning offers the potential to rapidly bring new therapies to market at a lower cost than traditional drug development.

This thesis will explore the potential of drug repositioning for liver diseases, focusing on the identification and validation of candidate drugs for the treatment of various liver conditions. By leveraging existing knowledge of drug mechanisms of action and disease pathology, this approach has the potential to accelerate the development of new treatments for liver diseases and improve patient outcomes.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of liver diseases
2.2 Current treatment options for liver diseases
2.3 Drug repositioning as a strategy for drug discovery
2.4 Case studies of successful drug repositioning for liver diseases
2.5 Challenges and limitations of drug repositioning
2.6 Computational methods for drug repositioning
2.7 Experimental validation of drug repositioning candidates
2.8 Regulatory considerations for repurposed drugs
2.9 Ethical and legal implications of drug repositioning
2.10 Future directions in drug repositioning for liver diseases

Chapter 3: Research Methodology
3.1 Study design
3.2 Data collection and analysis
3.3 Identification of candidate drugs for drug repositioning
3.4 In silico screening methods
3.5 In vitro validation of drug candidates
3.6 In vivo testing of repurposed drugs
3.7 Safety and toxicity assessment
3.8 Regulatory approval process

Chapter 4: Discussion of Findings
4.1 Identification of potential drug candidates for liver diseases
4.2 Validation of drug repositioning candidates
4.3 Efficacy and safety profiles of repurposed drugs
4.4 Comparison with existing treatment options
4.5 Implications for clinical practice
4.6 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Conclusions
5.3 Recommendations for future research
5.4 Implications for clinical practice

Thesis Overview on Drug Repositioning for Liver Diseases

Liver diseases represent a significant global health burden, with limited treatment options and high mortality rates. Drug repositioning, the process of identifying new therapeutic uses for existing drugs, offers a promising approach to finding novel treatments for these conditions. By leveraging existing knowledge of drug mechanisms of action and disease pathology, drug repositioning has the potential to accelerate the development of new therapies for liver diseases, improving patient outcomes and reducing healthcare costs.

This thesis aims to explore the potential of drug repositioning for liver diseases, with a focus on identifying and validating candidate drugs for the treatment of various liver conditions. Through a comprehensive review of the literature, analysis of existing drug databases, and experimental validation of drug candidates, this study seeks to demonstrate the efficacy and safety of repurposed drugs for liver diseases. By providing a detailed overview of the drug repositioning process, from identification of candidates to regulatory approval, this thesis aims to inform future research and clinical practice in the field of liver disease treatment.

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