Drug-induced drug reaction with eosinophilia and systemic symptoms (DRESS) biomarkers – Complete Phd and Masters Thesis

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Introduction

Drug-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and potentially life-threatening hypersensitivity reaction characterized by skin rash, fever, lymphadenopathy, organ involvement, and eosinophilia. It is a rare but serious adverse drug reaction that can be triggered by a variety of medications. The exact pathogenesis of DRESS is not well understood, and the diagnosis can be challenging due to similarities with other drug reactions. Early detection and treatment of DRESS are crucial to prevent complications and improve patient outcomes. Biomarkers are emerging as valuable tools in predicting, diagnosing, and monitoring the progression of DRESS. This thesis aims to explore the potential biomarkers associated with DRESS and their clinical implications.

1.1 Introduction
1.2 Background of the Study
1.3 Problem Statement
1.4 Objective of the Study
1.5 Limitation of the Study
1.6 Scope of the Study
1.7 Significance of the Study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 Overview of Drug-induced DRESS
2.2 Pathophysiology of DRESS
2.3 Clinical Presentation and Diagnosis
2.4 Management and Treatment
2.5 Biomarkers in DRESS
2.6 Genetic Factors in DRESS
2.7 Pharmacogenomics of DRESS
2.8 Immune Response in DRESS
2.9 Other Hypersensitivity Reactions
2.10 Current Research Trends

Chapter 3: Research Methodology
3.1 Research Design
3.2 Study Population
3.3 Data Collection Methods
3.4 Biomarker Selection
3.5 Data Analysis Techniques
3.6 Ethical Considerations
3.7 Pilot Study
3.8 Sampling Techniques

Chapter 4: Discussion of Findings
4.1 Biomarkers Associated with DRESS
4.2 Clinical Utility of Biomarkers
4.3 Predictive Value of Biomarkers
4.4 Challenges and Limitations
4.5 Future Directions
4.6 Comparison with Existing Literature
4.7 Clinical Implications
4.8 Recommendations for Practice

Chapter 5: Conclusion and Summary
5.1 Summary of Findings
5.2 Implications for Clinical Practice
5.3 Contributions to Existing Knowledge
5.4 Limitations and Future Research Directions
5.5 Conclusion

Thesis Overview on Drug-induced DRESS Biomarkers

Drug-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by a hypersensitivity response involving skin rash, fever, lymphadenopathy, and eosinophilia. Biomarkers have emerged as promising tools in the prediction, diagnosis, and monitoring of DRESS. This thesis aims to explore the potential biomarkers associated with DRESS and their clinical implications. The literature review will provide an overview of DRESS, including pathophysiology, clinical presentation, and treatment. The research methodology will outline the study design, population, data collection methods, and analysis techniques. The discussion of findings will focus on biomarkers associated with DRESS, their clinical utility, predictive value, challenges, and future directions. The conclusion and summary will summarize the findings, discuss implications for clinical practice, and suggest future research directions. This thesis aims to contribute to the understanding of biomarkers in DRESS and improve patient outcomes in clinical settings.

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