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Introduction

Drug delivery systems have revolutionized the field of healthcare by providing targeted and controlled release of therapeutic agents to specific sites within the body. With the advent of cutting-edge technologies such as Chimeric Antigen Receptor T-cell (CAR-T cell) therapy, the need for innovative drug delivery systems tailored to this new form of cancer treatment has become increasingly apparent.

CAR-T cell therapy involves genetically engineering a patient’s T cells to express chimeric antigen receptors that specifically target cancer cells. While this therapy has shown remarkable success in treating certain types of cancers, there are still challenges associated with its efficacy and safety. One such challenge is the delivery of CAR-T cells to the tumor site and ensuring their sustained presence and activity in the tumor microenvironment.

This thesis aims to explore the various drug delivery systems that can be utilized for CAR-T cell therapy to improve its therapeutic outcomes. By enhancing the targeted delivery and retention of CAR-T cells within the tumor, these drug delivery systems have the potential to maximize the efficacy of this promising cancer treatment modality.

Chapter One: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter Two: Literature Review
2.1 Current status of CAR-T cell therapy
2.2 Challenges in CAR-T cell therapy delivery
2.3 Principles of drug delivery systems
2.4 Types of drug delivery systems for CAR-T cell therapy
2.5 Nanoparticles for CAR-T cell delivery
2.6 Hydrogels for CAR-T cell delivery
2.7 Liposomes for CAR-T cell delivery
2.8 Microparticles for CAR-T cell delivery
2.9 Challenges and limitations of drug delivery systems for CAR-T cell therapy
2.10 Future directions in drug delivery systems for CAR-T cell therapy

Chapter Three: Research Methodology
3.1 Research design
3.2 Selection of study participants
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Pilot study
3.7 Validation of results
3.8 Statistical analysis

Chapter Four: Discussion of Findings
4.1 Summary of findings
4.2 Comparison of different drug delivery systems for CAR-T cell therapy
4.3 Implications of findings
4.4 Challenges and future directions
4.5 Recommendations for clinical practice
4.6 Contributions to the field
4.7 Limitations of the study
4.8 Areas for future research

Chapter Five: Conclusion and Summary
5.1 Summary of key findings
5.2 Contribution to the field
5.3 Implications for clinical practice
5.4 Recommendations for future research
5.5 Conclusion

This thesis will provide a comprehensive overview of drug delivery systems for CAR-T cell therapy, aiming to contribute to the advancement of this innovative cancer treatment modality. By exploring the various strategies for improving the delivery of CAR-T cells to tumor sites, this research aims to pave the way for enhanced therapeutic outcomes and improved patient outcomes in the field of oncology.

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