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Introduction

The aging process is a complex phenomenon that affects all living organisms, including humans. It is characterized by a decline in physiological functions and an increased risk of various age-related diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. One of the key factors that contribute to aging is the accumulation of DNA damage over time, leading to genomic instability and cellular dysfunction.

DNA repair mechanisms play a critical role in maintaining genomic integrity and preventing the accumulation of DNA damage. These mechanisms are essential for the repair of various types of DNA lesions, such as single-strand breaks, double-strand breaks, and base modifications, which can arise from endogenous and exogenous sources. Dysregulation of DNA repair pathways has been linked to accelerated aging and increased susceptibility to age-related diseases.

This thesis aims to provide a comprehensive overview of DNA repair mechanisms and their impact on the aging process. The study will explore the molecular pathways involved in DNA repair, the factors influencing their efficiency, and their implications for aging and age-related diseases. By gaining a better understanding of how DNA repair mechanisms function in the context of aging, we may uncover potential targets for therapeutic interventions to improve healthspan and lifespan.

Table of Contents

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of Terms

Chapter 2: Literature Review
2.1 DNA repair mechanisms
2.2 Types of DNA damage
2.3 Cellular consequences of DNA damage
2.4 Aging and DNA repair
2.5 Role of DNA repair in age-related diseases
2.6 Factors influencing DNA repair efficiency
2.7 Molecular pathways involved in DNA repair
2.8 Therapeutic strategies targeting DNA repair
2.9 Experimental models for studying DNA repair and aging
2.10 Current challenges and future directions

Chapter 3: Research Methodology
3.1 Research design
3.2 Sample selection
3.3 Data collection methods
3.4 Data analysis techniques
3.5 Ethical considerations
3.6 Statistical analysis
3.7 Validity and reliability
3.8 Research limitations

Chapter 4: Discussion of Findings
4.1 Overview of research findings
4.2 Relationship between DNA repair mechanisms and aging
4.3 Implications for age-related diseases
4.4 Comparative analysis with existing literature
4.5 Potential therapeutic targets
4.6 Future research directions
4.7 Strengths and limitations of the study

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Implications for aging research
5.3 Recommendations for future studies
5.4 Concluding remarks

By exploring the intricate relationship between DNA repair mechanisms and aging, this thesis aims to shed light on the underlying mechanisms driving the aging process and provide insights into potential interventions to promote healthy aging.

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