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Introduction:

Cyclodextrins are cyclic oligosaccharides that have garnered significant attention in the pharmaceutical field due to their potential in improving the solubility and stability of poorly water-soluble drugs. The unique structure of cyclodextrins allows them to form inclusion complexes with various guest molecules, thereby enhancing their bioavailability and therapeutic efficacy. This thesis aims to explore the development of cyclodextrin-based drug delivery systems and their application in the field of pharmacology.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Overview of cyclodextrins
2.2 Properties of cyclodextrins
2.3 Cyclodextrins in drug delivery
2.4 Formulation approaches using cyclodextrins
2.5 Enhanced solubility and bioavailability of drugs with cyclodextrins
2.6 Cyclodextrins as drug carriers
2.7 Inclusion complexation of cyclodextrins
2.8 Applications of cyclodextrin-based drug delivery systems
2.9 Challenges and future directions in cyclodextrin research
2.10 Summary of literature review

Chapter 3: Research Methodology
3.1 Research design
3.2 Selection of cyclodextrins and drugs
3.3 Formulation of cyclodextrin-based drug delivery systems
3.4 Characterization of drug complexes
3.5 In vitro drug release studies
3.6 Pharmacokinetic evaluation
3.7 Stability studies
3.8 Statistical analysis
3.9 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Formulation optimization
4.2 Characterization of drug complexes
4.3 In vitro drug release profiles
4.4 Pharmacokinetic parameters
4.5 Stability evaluation
4.6 Comparison with conventional drug delivery systems
4.7 Mechanistic insights
4.8 Implications for drug delivery
4.9 Future research directions

Chapter 5: Conclusion and Summary
5.1 Summary of key findings
5.2 Contributions to the field
5.3 Practical applications of cyclodextrin-based drug delivery systems
5.4 Limitations of the study
5.5 Recommendations for future research
5.6 Conclusion

Thesis Overview:

The development of cyclodextrin-based drug delivery systems has revolutionized the field of pharmaceutics by offering innovative solutions to enhance drug solubility, stability, and bioavailability. This thesis focuses on investigating the potential of cyclodextrins as versatile carriers for delivering a wide range of therapeutic agents. The systematic approach includes a comprehensive literature review to establish the current knowledge base, followed by a detailed research methodology to design and evaluate cyclodextrin-based formulations. The discussion of findings provides insights into the optimization and characterization of drug complexes, in vitro release profiles, pharmacokinetic behavior, and stability of the formulations. The conclusion summarizes the key findings, implications for drug delivery, and future research directions in the field. Overall, this thesis contributes to advancing the understanding and application of cyclodextrin-based drug delivery systems in pharmaceutical sciences.

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