Introduction

The detection and quantification of biomarkers in clinical samples play a critical role in disease diagnosis, prognosis, and monitoring of treatment efficacy. Conventional detection methods often lack sensitivity, specificity, and speed, leading to delays in accurate diagnosis and treatment decisions. Biosensing platforms have emerged as promising tools for the detection of biomarkers due to their enhanced sensitivity, specificity, and rapid analysis capabilities. This thesis focuses on developing novel biosensing platforms for the detection of biomarkers in clinical samples to improve diagnostic accuracy and patient outcomes.

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter Two: Literature Review
– History of biomarker detection
– Types of biosensing platforms
– Applications of biosensing platforms in clinical diagnostics
– Challenges in biomarker detection
– Emerging trends in biosensing technology
– Examples of successful biosensing platforms
– Comparison of different biosensing platforms
– Potential areas for improvement in biosensing technology
– Regulatory considerations for biosensing platforms
– Future prospects for biosensing technology

Chapter Three: Research Methodology
– Selection of biomarkers and clinical samples
– Design and fabrication of biosensing platforms
– Optimization of biosensing platform performance
– Validation of biosensing platform sensitivity and specificity
– Comparison of biosensing platform with existing methods
– Statistical analysis of data
– Ethical considerations in research
– Budget and timeline for research

Chapter Four: Discussion of Findings
– Performance evaluation of biosensing platforms
– Comparison of biosensing platforms with existing methods
– Interpretation of results
– Implications of findings for clinical practice
– Future directions for research and development

Chapter Five: Conclusion and Summary
– Summary of key findings
– Limitations of the study
– Recommendations for future research
– Conclusion and implications for clinical practice

Thesis Overview

Developing novel biosensing platforms for the detection of biomarkers in clinical samples is crucial for improving disease diagnosis and patient outcomes. This thesis aims to explore the potential of biosensing technology in enhancing biomarker detection in clinical samples. The literature review will provide a comprehensive overview of the history, types, applications, challenges, and trends in biosensing technology. The research methodology will detail the selection of biomarkers, design, optimization, and validation of biosensing platforms. The discussion of findings will present the results of performance evaluation, interpretation of data, and implications for clinical practice. The conclusion will summarize key findings, discuss limitations, provide recommendations for future research, and highlight the significance of this study in advancing biosensing technology for clinical applications.

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