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Introduction

Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that play a critical role in maintaining genomic stability and regulating cell proliferation. The maintenance of telomeres is essential for preserving the integrity of the genome and preventing the onset of diseases such as cancer and aging-related conditions. Telomere length is tightly regulated by a complex interplay of biochemical processes, including telomerase-mediated extension and alternative lengthening mechanisms.

This thesis aims to provide a comprehensive overview of the biochemical mechanisms involved in telomere maintenance, with a focus on the role of telomerase and other proteins in regulating telomere length and function. The study will also explore the implications of telomere dysfunction in disease pathogenesis and potential therapeutic strategies for targeting telomeres in cancer and other age-related disorders.

Chapter 1: Introduction
1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the Thesis
1.9 Definition of terms

Chapter 2: Literature Review
2.1 Telomere structure and function
2.2 Telomerase and its role in telomere maintenance
2.3 Alternative lengthening mechanisms
2.4 Telomere regulation in aging and disease
2.5 Telomeres as therapeutic targets in cancer
2.6 Telomere biology in stem cells
2.7 Telomere dynamics in cellular senescence
2.8 Telomere maintenance in model organisms
2.9 Telomere lengthening strategies
2.10 Telomere dysfunction in aging-related disorders

Chapter 3: Research Methodology
3.1 Study design
3.2 Sample collection and analysis
3.3 Telomere length measurement techniques
3.4 Cellular assays for telomere function
3.5 Biochemical assays for telomerase activity
3.6 Molecular techniques for telomere research
3.7 Statistical analysis
3.8 Ethical considerations

Chapter 4: Discussion of Findings
4.1 Telomere length dynamics in cancer cells
4.2 Telomerase regulation in stem cell populations
4.3 Role of telomeres in aging processes
4.4 Therapeutic targeting of telomeres in cancer
4.5 Telomere dysfunction in non-cancer diseases
4.6 Molecular pathways regulating telomere maintenance
4.7 Telomere shortening and disease susceptibility
4.8 Clinical implications of telomere research

Chapter 5: Conclusion and Summary
In conclusion, this thesis provides a comprehensive overview of the biochemical mechanisms involved in telomere maintenance and their implications for disease pathogenesis. The study highlights the critical role of telomeres in preserving genomic stability and regulating cellular proliferation, with potential therapeutic avenues for targeting telomeres in cancer and other age-related disorders. Future research directions in telomere biology and potential clinical applications of telomere research are also discussed.

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